| H01656 | |
| H number | H01656 |
| Name | Psoriasis |
| Description | Psoriasis (PSORS) is a chronic, immune-mediated inflammatory skin disease, characterized by increased propagation of the epidermis with dilation of dermal capillaries. The major symptoms of psoriasis are itchy, scaly, and flaky skin, swelling, pain, and disfiguring skin lesions. Plaque psoriasis is the most common form. Other forms include flexural, guttate, nail, inverse psoriasis, erythroderma, and psoriatic arthritis. |
| Category | Immune system disease; Skin disease |
| Network | - |
| Gene | (PSORS1) HLA-C [HSA:3107] [KO:K06751] (PSORS2) CARD14 [HSA:79092] [KO:K20913] (PSORS13) TRAF3IP2 [HSA:10758] [KO:K21124] (PSORS14) IL36RN [HSA:26525] [KO:K05483] (PSORS15) AP1S3 [HSA:130340] [KO:K12395] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | Dexamethasone sodium phosphate [DR:D00975] Hydrocortisone [DR:D00088] Prednisolone [DR:D00472] Betamethasone dipropionate [DR:D01637] Calcitriol [DR:D00129] Anthralin [DR:D00233] Methoxsalen [DR:D00139] Calcipotriene [DR:D01125] Calcipotriol hydrate [DR:D10198] Tazarotene [DR:D01132] Calcipotriene and betamethasone dipropionate [DR:D10534] Halobetasol and tazarotene [DR:D11932] Acitretin [DR:D02754] Methylprednisolone [DR:D00407] Desoximetasone [DR:D03697] Halobetasol propionate [DR:D04409] Clobetasol propionate [DR:D01272] Corticotropin [DR:D00146] Cortisone acetate [DR:D00973] Methotrexate [DR:D00142] Methotrexate sodium [DR:D02115] Tofacitinib citrate [DR:D09783] Apremilast [DR:D08860] Deucravacitinib [DR:D11817] Etanercept [DR:D00742] Infliximab [DR:D02598] Adalimumab [DR:D02597] Ustekinumab [DR:D09214] Secukinumab [DR:D09967] Brodalumab [DR:D10061] Ixekizumab [DR:D10071] Guselkumab [DR:D10438] Tildrakizumab [DR:D10400] Risankizumab [DR:D11052] Cyclosporine [DR:D00184] Roflumilast [DR:D05744] Tapinarof [DR:D11365] |
| Comment | - |
| Other DBs | ICD-11: EA90 ICD-10: L40 MeSH: D011565 OMIM: 177900 602723 614070 614204 616106 |
| Reference | PMID:23668525 AUTHORS Weigle N, McBane S TITLE Psoriasis. JOURNAL Am Fam Physician 87:626-33 (2013) PMID:25679142 AUTHORS Limaye K TITLE Psoriasis: an overview and update. JOURNAL Nurse Pract 40:23-6 (2015) DOI:10.1097/01.NPR.0000453651.30695.43 PMID:10888604 (PSORS1) AUTHORS Asumalahti K, Laitinen T, Itkonen-Vatjus R, Lokki ML, Suomela S, Snellman E, Saarialho-Kere U, Kere J TITLE A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele. JOURNAL Hum Mol Genet 9:1533-42 (2000) DOI:10.1093/hmg/9.10.1533 PMID:22521418 (PSORS2) AUTHORS Jordan CT, Cao L, Roberson ED, Pierson KC, Yang CF, Joyce CE, Ryan C, Duan S, Helms CA, Liu Y, Chen Y, McBride AA, Hwu WL, Wu JY, Chen YT, Menter A, Goldbach-Mansky R, Lowes MA, Bowcock AM TITLE PSORS2 is due to mutations in CARD14. JOURNAL Am J Hum Genet 90:784-95 (2012) DOI:10.1016/j.ajhg.2012.03.012 PMID:20953186 (PSORS13) AUTHORS Huffmeier U, Uebe S, Ekici AB, Bowes J, Giardina E, Korendowych E, Juneblad K, Apel M, McManus R, Ho P, Bruce IN, Ryan AW, Behrens F, Lascorz J, Bohm B, Traupe H, Lohmann J, Gieger C, Wichmann HE, Herold C, Steffens M, Klareskog L, Wienker TF, Fitzgerald O, Alenius GM, McHugh NJ, Novelli G, Burkhardt H, Barton A, Reis A TITLE Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis. JOURNAL Nat Genet 42:996-9 (2010) DOI:10.1038/ng.688 PMID:22903787 (PSORS14) AUTHORS Farooq M, Nakai H, Fujimoto A, Fujikawa H, Matsuyama A, Kariya N, Aizawa A, Fujiwara H, Ito M, Shimomura Y TITLE Mutation analysis of the IL36RN gene in 14 Japanese patients with generalized pustular psoriasis. JOURNAL Hum Mutat 34:176-83 (2013) DOI:10.1002/humu.22203 PMID:24791904 (PSORS15) AUTHORS Setta-Kaffetzi N, Simpson MA, Navarini AA, Patel VM, Lu HC, Allen MH, Duckworth M, Bachelez H, Burden AD, Choon SE, Griffiths CE, Kirby B, Kolios A, Seyger MM, Prins C, Smahi A, Trembath RC, Fraternali F, Smith CH, Barker JN, Capon F TITLE AP1S3 mutations are associated with pustular psoriasis and impaired Toll-like receptor 3 trafficking. JOURNAL Am J Hum Genet 94:790-7 (2014) DOI:10.1016/j.ajhg.2014.04.005 |