| H01665 | |
| H number | H01665 |
| Name | Primary peritoneal carcinoma |
| Description | Female primary peritoneal carcinoma (PPC) has the characteristic of diffuse involvement of the peritoneum by papillary carcinoma in the absence of an obvious primary site and grossly normal ovaries, or minimal involvement. It is histologically indistinguishable from primary epithelial ovarian carcinoma (EOC) and is diagnosed in the absence of another identifiable primary. Most reported PPC cases are primary peritoneal serous papillary carcinoma (PPSPC), while peritoneal mixed epithelial carcinoma (MEC) and malignant mixed Mullerian tumor (MMMT) are rarely reported. Germline BRCA1 mutations in 26% of PPSPC patients was detected. BRCA1 mutation carriers had a higher overall incidence of p53 mutations than wildtype BRCA1 case subjects. It is suggested that p53 has a unique role in the development and progression of BRCA1-related PPSPC. |
| Category | Cancer |
| Network | - |
| Gene | BRCA1 (mutation) [HSA:672] [KO:K10605] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | Bevacizumab [DR:D06409] Niraparib tosilate hydrate [DR:D11895] (BRCA-mutated) Mirvetuximab soravtansine [DR:D10954] (folate receptor alpha positive) |
| Comment | - |
| Other DBs | ICD-11: 2C51 ICD-10: C48.1 MeSH: D010534 |
| Reference | PMID:11014956 AUTHORS Cormio G, Di Vagno G, Di Gesu G, Mastroianni M, Melilli GA, Vimercati A, Putignano G, Loverro G, Selvaggi L TITLE Primary peritoneal carcinoma: a report of twelve cases and a review of the literature. JOURNAL Gynecol Obstet Invest 50:203-6 (2000) DOI:10.1159/000010311 PMID:19897383 AUTHORS Pentheroudakis G, Pavlidis N TITLE Serous papillary peritoneal carcinoma: unknown primary tumour, ovarian cancer counterpart or a distinct entity? A systematic review. JOURNAL Crit Rev Oncol Hematol 75:27-42 (2010) DOI:10.1016/j.critrevonc.2009.10.003 PMID:10728699 AUTHORS Schorge JO, Muto MG, Lee SJ, Huang LW, Welch WR, Bell DA, Keung EZ, Berkowitz RS, Mok SC TITLE BRCA1-related papillary serous carcinoma of the peritoneum has a unique molecular pathogenesis. JOURNAL Cancer Res 60:1361-4 (2000) PMID:21352070 AUTHORS Slomovitz BM, Worley MJ, Markman M, Coleman RL TITLE Emerging therapeutics for primary peritoneal cancer. JOURNAL Expert Opin Emerg Drugs 16:71-84 (2011) DOI:10.1517/14728214.2011.526600 PMID:18543395 AUTHORS Zhang C, Li XP, Cui H, Shen DH, Wei LH TITLE Advanced primary peritoneal carcinoma: clinicopathological and prognostic factor analyses. JOURNAL J Zhejiang Univ Sci B 9:435-40 (2008) DOI:10.1631/jzus.B0820051 PMID:25315029 AUTHORS Keating GM TITLE Bevacizumab: a review of its use in advanced cancer. JOURNAL Drugs 74:1891-925 (2014) DOI:10.1007/s40265-014-0302-9 |