| H01670 | |
| H number | H01670 |
| Name | Social anxiety disorder; Social phobia |
| Description | Social anxiety disorder (SAD) is the most common anxiety disorder. SAD is generally considered a chronic disorder and has its onset during early adolescence. It is a risk factor for subsequent depressive illness and substance abuse. Patients with SAD have an extreme fear of being negatively evaluated in social situations and, as a result, avoid social events or endure them with excessive fear or anxiety. Although the etiology of SAD is not yet fully established, twin and family studies suggest that SAD is heritable. Functional neuroimaging studies point to increased activity in amygdala and insula in patients with social anxiety disorder. In addition, there is evidence from various studies, that the serotonin, and dopamine neurotransmitter systems mediate the symptoms of SAD. A range of effective cognitive behavioural and pharmacological treatments now exists. However, they don't work for the 30-40% of patients. |
| Category | Mental and behavioural disorder |
| Network | - |
| Gene | - |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | Paroxetine hydrochloride hemihydrate [DR:D02260] Paroxetine hydrochloride [DR:D05374] Sertraline hydrochloride [DR:D00825] Venlafaxine hydrochloride [DR:D00821] |
| Comment | - |
| Other DBs | ICD-11: 6B04 ICD-10: F40.1 F93.2 MeSH: D010698 |
| Reference | PMID:18374843 AUTHORS Stein MB, Stein DJ TITLE Social anxiety disorder. JOURNAL Lancet 371:1115-25 (2008) DOI:10.1016/S0140-6736(08)60488-2 PMID:27593443 AUTHORS Bas-Hoogendam JM, Blackford JU, Bruhl AB, Blair KS, van der Wee NJA, Westenberg PM TITLE Neurobiological candidate endophenotypes of social anxiety disorder. JOURNAL Neurosci Biobehav Rev 71:362-378 (2016) DOI:10.1016/j.neubiorev.2016.08.040 PMID:16899354 AUTHORS Lochner C, Hemmings S, Seedat S, Kinnear C, Schoeman R, Annerbrink K, Olsson M, Eriksson E, Moolman-Smook J, Allgulander C, Stein DJ TITLE Genetics and personality traits in patients with social anxiety disorder: a case-control study in South Africa. JOURNAL Eur Neuropsychopharmacol 17:321-7 (2007) DOI:10.1016/j.euroneuro.2006.06.010 |