| H01673 | |
| H number | H01673 |
| Name | Palmoplantar keratoderma |
| Description | Palmoplantar keratodermas (PPK) comprise a heterogeneous group of keratinization disorders with hyperkeratotic thickening of palms and soles. Sporadic or acquired forms of PPKs and hereditary forms exist. The causes of acquired PPK vary, and include exposure to certain chemicals, side effects of certain drugs, and metabolic disorders. There is as yet no cure for hereditary PPK. In patients with acquired PPK, the cause should be treated or eliminated, if possible. In both instances, optimized treatment can lead to a significant improvement in symptoms. Topical therapy with urea-based ointments improves the skin's absorption of moisture and has keratolytic effects. Topical vitamin D therapy is another option. |
| Category | Congenital malformation |
| Network | - |
| Gene | - |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | - |
| Comment | Hereditary PPK are divided morphologically into four types; diffuse, focal, striate and punctate. PPK can be further subdivided histologically into epidermolytic and nonepidermolytic PPK. |
| Other DBs | ICD-11: ED55 ICD-10: L85.1 MeSH: D007645 OMIM: 144200 |
| Reference | PMID:25176457 AUTHORS Schiller S, Seebode C, Hennies HC, Giehl K, Emmert S TITLE Palmoplantar keratoderma (PPK): acquired and genetic causes of a not so rare disease. JOURNAL J Dtsch Dermatol Ges 12:781-8 (2014) DOI:10.1111/ddg.12418 PMID:26945534 AUTHORS Sakiyama T, Kubo A TITLE Hereditary palmoplantar keratoderma "clinical and genetic differential diagnosis". JOURNAL J Dermatol 43:264-74 (2016) DOI:10.1111/1346-8138.13219 PMID:8595410 AUTHORS Shamsher MK, Navsaria HA, Stevens HP, Ratnavel RC, Purkis PE, Kelsell DP, McLean WH, Cook LJ, Griffiths WA, Gschmeissner S, et al. TITLE Novel mutations in keratin 16 gene underly focal non-epidermolytic palmoplantar keratoderma (NEPPK) in two families. JOURNAL Hum Mol Genet 4:1875-81 (1995) DOI:10.1093/hmg/4.10.1875 |