| H01676 | |
| H number | H01676 |
| Name | Normal pressure hydrocephalus |
| Description | Normal pressure hydrocephalus (NPH) is a progressive brain disease characterized by gait impairment, urinary incontinence, and dementia, and by ventricular enlargement in the absence of elevated intracranial pressure. NPH can be secondary to disease processes that cause inflammation of the arachnoid, such as subarachnoid hemorrhage, traumatic brain injury, or meningitis. As many as half of patients with NPH have no identifiable risk factor, and it is called idiopathic normal pressure hydrocephalus (INPH). Although INPH is usually considered an acquired form of hydrocephalus because the onset of symptoms is not until late in life, it has been reported that a subset of patients with INPH may actually have congenital hydrocephalus. Symptoms can be alleviated with a cerebrospinal fluid (CSF) shunt. |
| Category | Nervous system disease |
| Network | - |
| Gene | - |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | - |
| Comment | - |
| Other DBs | ICD-11: 8D64.04 ICD-10: G91.2 MeSH: D006850 OMIM: 236690 611808 |
| Reference | PMID:25061869 AUTHORS Golz L, Ruppert FH, Meier U, Lemcke J TITLE Outcome of modern shunt therapy in patients with idiopathic normal pressure hydrocephalus 6 years postoperatively. JOURNAL J Neurosurg 121:771-5 (2014) DOI:10.3171/2014.6.JNS131211 PMID:17202229 AUTHORS Wilson RK, Williams MA TITLE Evidence that congenital hydrocephalus is a precursor to idiopathic normal pressure hydrocephalus in only a subset of patients. JOURNAL J Neurol Neurosurg Psychiatry 78:508-11 (2007) DOI:10.1136/jnnp.2006.108761 PMID:16239882 (treatment) AUTHORS McGirt MJ, Woodworth G, Coon AL, Thomas G, Williams MA, Rigamonti D TITLE Diagnosis, treatment, and analysis of long-term outcomes in idiopathic normal-pressure hydrocephalus. JOURNAL Neurosurgery 57:699-705; discussion 699-705 (2005) DOI:10.1227/01.NEU.0000175724.00147.10 PMID:18203159 AUTHORS Zhang J, Williams MA, Rigamonti D TITLE Heritable essential tremor-idiopathic normal pressure hydrocephalus (ETINPH). JOURNAL Am J Med Genet A 146A:433-9 (2008) DOI:10.1002/ajmg.a.31958 |