| H01680 | |
| H number | H01680 |
| Name | Chronic pancreatitis |
| Description | Chronic pancreatitis is a progressive inflammatory disease of the pancreas that will finally result in both exocrine and endocrine insufficiency. Chronic pancreatitis develops gradually and worsens over time, resulting in permanent organ damage. It is usually caused by recurrent episodes of pancreatic necro-inflammation, leading to pancreatic atrophy and dysfunction. It manifests clinically as maldigestion, weight loss, abdominal pain and eventually diabetes. Six major etiologies for chronic pancreatitis have been identified, namely toxic-metabolic (including alcohol), idiopathic, genetic, autoimmune, recurrent and severe acute pancreatitis, and obstruction. Oral protease inhibitors are currently used as a medical treatment for chronic pancreatitis. |
| Category | Digestive system disease |
| Network | - |
| Gene | - |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | Pancrelipase [DR:D05349] |
| Comment | See also H00933 Hereditary pancreatitis. |
| Other DBs | ICD-11: DC32 ICD-10: K86.1 MeSH: D050500 OMIM: 167800 |
| Reference | PMID:20567557 AUTHORS Banks PA, Conwell DL, Toskes PP TITLE The management of acute and chronic pancreatitis. JOURNAL Gastroenterol Hepatol (N Y) 6:1-16 (2010) PMID:18442214 AUTHORS Frossard JL, Dumonceau JM, Pastor C, Spahr L, Hadengue A TITLE Concomitant autoimmune and genetic pancreatitis leads to severe inflammatory conditions. JOURNAL World J Gastroenterol 14:2596-8 (2008) DOI:10.3748/wjg.14.2596 PMID:25228979 AUTHORS Hirano K, Saito T, Mizuno S, Tada M, Sasahira N, Isayama H, Matsukawa M, Umefune G, Akiyama D, Saito K, Kawahata S, Takahara N, Uchino R, Hamada T, Miyabayashi K, Mohri D, Sasaki T, Kogure H, Yamamoto N, Nakai Y, Koike K TITLE Total cholesterol level for assessing pancreatic insufficiency due to chronic pancreatitis. JOURNAL Gut Liver 8:563-8 (2014) DOI:10.5009/gnl13366 PMID:17625311 AUTHORS Motoo Y TITLE Antiproteases in the treatment of chronic pancreatitis. JOURNAL JOP 8:533-7 (2007) PMID:17625312 AUTHORS Kitagawa M, Hayakawa T TITLE Antiproteases and the pancreas: basic and clinical update. Conclusion remarks. JOURNAL JOP 8:538-44 (2007) |