| H01714 | |
| H number | H01714 |
| Name | Chronic obstructive pulmonary disease (COPD); Emphysema |
| Description | Chronic obstructive pulmonary disease (COPD) is a representative chronic inflammatory disorder of the lungs that includes chronic bronchitis and emphysema. COPD is characterized by airway inflammation and progressive airflow obstruction, most commonly caused by cigarette smoking. The major symptoms of which patients complain are cough, breathlessness, and sputum production. COPD is associated with underlying inflammation in response to chronic exposure to noxious particulates and gases and with a number of comorbid conditions. The onset of COPD generally occurs in the 6th to 8th decades of life. Early onset COPD is defined as disease onset before the age of 50 years, irrespective of smoking history. The presence of persons with early onset, severely reduced pulmonary function suggests that individuals may vary in their genetic susceptibility to the effects of smoking. Alpha-1-antitrypsin deficiency is the only proven genetic risk factor for COPD. Bronchodilators are the mainstay of treatment since they improve lung function and reduce acute exacerbations. Long-acting inhaled bronchodilators are recommended as first line treatment for patients with persistent symptoms. |
| Category | Respiratory system disease |
| Network | - |
| Gene | SERPINA1 [HSA:5265] [KO:K03984] HMOX1 [HSA:3162] [KO:K00510] MMP1 [HSA:4312] [KO:K01388] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | Prednisolone sodium phosphate [DR:D00981] Glycopyrrolate [DR:D00540] Prednisone [DR:D00473] Salmeterol xinafoate and fluticasone propionate [DR:D08699] Ipratropium bromide [DR:D02212] Metaproterenol sulfate [DR:D00685] Terbutaline sulfate [DR:D00688] Salmeterol xinafoate [DR:D00687] Formoterol fumarate [DR:D01373] Formoterol fumarate hydrate [DR:D05277] Indacaterol maleate [DR:D09319] Olodaterol hydrochloride [DR:D10020] Budesonide and formoterol fumarate dihydrate [DR:D09595] Fluticasone furoate and vilanterol trifenatate [DR:D10501] Albuterol sulfate and ipratropium bromide [DR:D10256] Umeclidinium bromide and vilanterol [DR:D10533] Glycopyrronium bromide and indacaterol maleate [DR:D10505] Aclidinium bromide and formoterol fumarate [DR:D11857] Tiotropium and olodaterol [DR:D10744] Glycopyrrolate and formoterol [DR:D11036] Fluticasone furoate, umeclidinium bromide and vilanterol [DR:D11035] Tiotropium bromide hydrate [DR:D01929] Aclidinium bromide [DR:D08837] Umeclidinium bromide [DR:D10181] Revefenacin [DR:D10978] Aminophylline hydrate [DR:D05429] Aminophylline dihydrate [DR:D11630] Theophylline and dextrose [DR:D10297] Roflumilast [DR:D05744] Acetylcysteine [DR:D00221] Arformoterol tartrate [DR:D02981] |
| Comment | See also H01103 Alpha-1-antitrypsin (A1AT) deficiency |
| Other DBs | ICD-11: CA22 ICD-10: J43 J44 MeSH: D029424 OMIM: 606963 |
| Reference | PMID:18046867 AUTHORS Smith J, Woodcock A TITLE Cough and its importance in COPD. JOURNAL Int J Chron Obstruct Pulmon Dis 1:305-14 (2006) DOI:10.2147/copd.2006.1.3.305 PMID:23257530 AUTHORS Tsuchida T, Matsuse H, Nishino T, Kawano T, Fukushima C, Hayashi T, Kohno S TITLE Pathologically confirmed, early-onset, severe chronic obstructive pulmonary disease. JOURNAL Intern Med 51:3411-4 (2012) DOI:10.2169/internalmedicine.51.8331 PMID:9620904 AUTHORS Silverman EK, Chapman HA, Drazen JM, Weiss ST, Rosner B, Campbell EJ, O'DONNELL WJ, Reilly JJ, Ginns L, Mentzer S, Wain J, Speizer FE TITLE Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis. JOURNAL Am J Respir Crit Care Med 157:1770-8 (1998) DOI:10.1164/ajrccm.157.6.9706014 PMID:10631150 AUTHORS Yamada N, Yamaya M, Okinaga S, Nakayama K, Sekizawa K, Shibahara S, Sasaki H TITLE Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. JOURNAL Am J Hum Genet 66:187-95 (2000) DOI:10.1086/302729 PMID:11875051 AUTHORS Joos L, He JQ, Shepherdson MB, Connett JE, Anthonisen NR, Pare PD, Sandford AJ TITLE The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function. JOURNAL Hum Mol Genet 11:569-76 (2002) DOI:10.1093/hmg/11.5.569 |