| H01729 | |
| H number | H01729 |
| Name | Premature ventricular complexes; Premature ventricular contractions |
| Description | Premature ventricular complex (PVC) is characterized by the premature occurrence of a QRS complex that is bizarre in shape and lasts longer than 120 msec. The T wave is large and usually of opposite polarity to the QRS complex. A PVC is usually followed by a full compensatory pause. PVCs are commonly encountered in apparently healthy individuals with a reported incidence of approximately 1% on standard 12-lead electrocardiograms (ECG) and 40% to 75% on routine 24 hour to 48 hour Holter monitoring. The clinical presentation may range from asymptomatic to left ventricular (LV) dysfunction with congestive heart failure. In many patients, ectopic ventricular events manifest as asymptomatic, isolated PVCs that have a benign prognosis in those without structural heart disease. In others, PVCs may be frequent and highly symptomatic, presenting as palpitations, chest discomfort, or presyncope. Clinical evidence suggests that frequent PVCs (variably defined in the literature) are more strongly associated with concomitant cardiac disease. The decision to suppress PVCs is largely based on the presence of symptoms, interference with other therapy (e.g., cardiac resynchronization therapy), or suspicion of PVC-mediated cardiomyopathy. When necessary, treatment for PVCs involves beta-blockers, calcium channel blockers, or other antiarrhythmic drugs and catheter ablation in selected cases. Catheter ablation of frequent PVCs has been demonstrated to be effective at PVC suppression and is associated with improvement or normalization of ventricular function. |
| Category | Cardiovascular disease |
| Network | - |
| Gene | - |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | - |
| Comment | - |
| Other DBs | ICD-11: 7A42 ICD-10: I49.1 I49.2 I49.3 I49.4 MeSH: D018879 |
| Reference | PMID:25741605 AUTHORS Eugenio PL TITLE Frequent Premature Ventricular Contractions: An Electrical Link to Cardiomyopathy. JOURNAL Cardiol Rev 23:168-72 (2015) DOI:10.1097/CRD.0000000000000063 PMID:25678299 AUTHORS Saurav A, Smer A, Abuzaid A, Bansal O, Abuissa H TITLE Premature ventricular contraction-induced cardiomyopathy. JOURNAL Clin Cardiol 38:251-8 (2015) DOI:10.1002/clc.22371 PMID:23733905 AUTHORS Cantillon DJ TITLE Evaluation and management of premature ventricular complexes. JOURNAL Cleve Clin J Med 80:377-87 (2013) DOI:10.3949/ccjm.80a.12168 PMID:22875587 AUTHORS Adams JC, Srivathsan K, Shen WK TITLE Advances in management of premature ventricular contractions. JOURNAL J Interv Card Electrophysiol 35:137-49 (2012) DOI:10.1007/s10840-012-9698-x PMID:12086238 AUTHORS Hebbar AK, Hueston WJ TITLE Management of common arrhythmias: Part II. Ventricular arrhythmias and arrhythmias in special populations. JOURNAL Am Fam Physician 65:2491-6 (2002) |