| H01742 | |
| H number | H01742 |
| Name | Coronary artery disease |
| Description | Coronary artery disease (CAD) is one of the leading causes of death globally. CAD is coupled to a pathogenic process in which lipids and lipoproteins accumulate in the subendothelial intimal layer of the vessel wall. A variety of environmental and genetic risk factors are associated with CAD, including hypercholesterolemia, hypertension, obesity, diabetes, and a family history of early CAD. It has been reported that an autosomal dominant form of CAD is caused by the mutation in transcription factor MEF2A. A missense mutation in LRP6, which encodes a co-receptor in the Wnt signaling pathway, has also been identified. |
| Category | Cardiovascular disease |
| Network | - |
| Gene | (ADCAD1) MEF2A [HSA:4205] [KO:K09260] (ADCAD2) LRP6 [HSA:4040] [KO:K03068] (CHDS1) CX3CR1 [HSA:1524] [KO:K04192] (CHDS5) KALRN [HSA:8997] [KO:K15048] (CHDS6) MMP3 [HSA:4314] [KO:K01394] (CHDS7) CD36 [HSA:948] [KO:K06259] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | Nitroglycerin [DR:D00515] Niacin [DR:D00049] Amlodipine benzoate [DR:D11881] Perindopril erbumine [DR:D00624] Amlodipine besilate and atorvastatin calcium [DR:D08488] |
| Comment | - |
| Other DBs | ICD-11: BA8Z ICD-10: I25.1 MeSH: D003324 OMIM: 608320 610947 607339 608901 614466 610938 |
| Reference | PMID:14657507 AUTHORS Olson EN TITLE Coronary artery disease and the MEF2A transcription factor. JOURNAL Sci Aging Knowledge Environ 2003:pe33 (2003) DOI:10.1126/sageke.2003.48.pe33 PMID:26044129 AUTHORS Grover MP, Ballouz S, Mohanasundaram KA, George RA, Goscinski A, Crowley TM, Sherman CD, Wouters MA TITLE Novel therapeutics for coronary artery disease from genome-wide association study data. JOURNAL BMC Med Genomics 8 Suppl 2:S1 (2015) DOI:10.1186/1755-8794-8-S2-S1 PMID:14645853 (MEF2A) AUTHORS Wang L, Fan C, Topol SE, Topol EJ, Wang Q TITLE Mutation of MEF2A in an inherited disorder with features of coronary artery disease. JOURNAL Science 302:1578-81 (2003) DOI:10.1126/science.1088477 PMID:17332414 (LRP6) AUTHORS Mani A, Radhakrishnan J, Wang H, Mani A, Mani MA, Nelson-Williams C, Carew KS, Mane S, Najmabadi H, Wu D, Lifton RP TITLE LRP6 mutation in a family with early coronary disease and metabolic risk factors. JOURNAL Science 315:1278-82 (2007) DOI:10.1126/science.1136370 PMID:11264153 (CX3CR1) AUTHORS Moatti D, Faure S, Fumeron F, Amara Mel-W, Seknadji P, McDermott DH, Debre P, Aumont MC, Murphy PM, de Prost D, Combadiere C TITLE Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease. JOURNAL Blood 97:1925-8 (2001) DOI:10.1182/blood.v97.7.1925 PMID:17357071 (KALRN) AUTHORS Wang L, Hauser ER, Shah SH, Pericak-Vance MA, Haynes C, Crosslin D, Harris M, Nelson S, Hale AB, Granger CB, Haines JL, Jones CJ, Crossman D, Seo D, Gregory SG, Kraus WE, Goldschmidt-Clermont PJ, Vance JM TITLE Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease. JOURNAL Am J Hum Genet 80:650-63 (2007) DOI:10.1086/512981 PMID:8662692 (MMP3) AUTHORS Ye S, Eriksson P, Hamsten A, Kurkinen M, Humphries SE, Henney AM TITLE Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression. JOURNAL J Biol Chem 271:13055-60 (1996) DOI:10.1074/jbc.271.22.13055 PMID:15282206 (CD36) AUTHORS Ma X, Bacci S, Mlynarski W, Gottardo L, Soccio T, Menzaghi C, Iori E, Lager RA, Shroff AR, Gervino EV, Nesto RW, Johnstone MT, Abumrad NA, Avogaro A, Trischitta V, Doria A TITLE A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians. JOURNAL Hum Mol Genet 13:2197-205 (2004) DOI:10.1093/hmg/ddh233 |