H01826 | |
H number | H01826 |
Name | Mesial temporal lobe epilepsy with hippocampal sclerosis |
Description | Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is a group of chronic disorders characterized by prominent neuronal loss and gliosis in the hippocampus and amygdala. MTLE-HS is restricted to patients in whom hippocampal atrophy and/or abnormal signal intensity on MRI, anterior temporal interictal epileptiform discharges, and additional evidence of temporal dysfunction on functional images and neuro-psychological assessment are demonstrated. Patients with MTLE-HS often have a history of early risk factors such as febrile seizures, status epilepticus (SE) or infection. A seizure-free period may ensue before uncontrolled partial seizures begin. Epileptic focus is located deeply in the mesial temporal region including mainly hippocampus, parahippocampal gyrus and amygdala. The anatomopathological hallmark is sclerosis of the hippocampus. Since most of the cases are drug resistant, epilepsy surgery is the current gold standard therapy option for cessation of seizures. Familial forms of MTLE-HS have been recognized, but no causal gene has been identified so far. |
Category | Nervous system disease |
Network | - |
Gene | - |
Pathogen | - |
Env factor | - |
Carcinogen | - |
Drug | - |
Comment | - |
Other DBs | ICD-11: 8A60.7 ICD-10: G40.2 MeSH: C566903 |
Reference | PMID:25809843 AUTHORS Jin SH, Jeong W, Chung CK TITLE Mesial temporal lobe epilepsy with hippocampal sclerosis is a network disorder with altered cortical hubs. JOURNAL Epilepsia 56:772-9 (2015) DOI:10.1111/epi.12966 PMID:21112221 AUTHORS Cersosimo R, Flesler S, Bartuluchi M, Soprano AM, Pomata H, Caraballo R TITLE Mesial temporal lobe epilepsy with hippocampal sclerosis: study of 42 children. JOURNAL Seizure 20:131-7 (2011) DOI:10.1016/j.seizure.2010.11.002 PMID:20663517 AUTHORS Yang T, Zhou D, Stefan H TITLE Why mesial temporal lobe epilepsy with hippocampal sclerosis is progressive: uncontrolled inflammation drives disease progression? JOURNAL J Neurol Sci 296:1-6 (2010) DOI:10.1016/j.jns.2010.06.002 PMID:27450765 AUTHORS Tekturk P, Erdogan ET, Kurt A, Vanli-Yavuz EN, Ekizoglu E, Kocagoncu E, Kucuk Z, Aksu S, Bebek N, Yapici Z, Gurses C, Gokyigit A, Baykan B, Karamursel S TITLE The effect of transcranial direct current stimulation on seizure frequency of patients with mesial temporal lobe epilepsy with hippocampal sclerosis. JOURNAL Clin Neurol Neurosurg 149:27-32 (2016) DOI:10.1016/j.clineuro.2016.07.014 |