| H01860 | |
| H number | H01860 |
| Name | Abnormal pituitary gonadotropin secretion |
| Description | There are two pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Their general biological roles are the stimulation of testicular and ovarian functions via the regulation of gametogenesis and steroid hormone synthesis in the gonads. Synthesis and release of FSH is triggered by the arrival of gonadotropin-releasing hormone (GnRH) from the hypothalamus. LH is synthesized similarly within the pituitary gland, requiring the same stimulus as FSH, the GnRH from the hypothalamus. Both hypothalamic abnormalities and intrinsic pituitary abnormalities can cause an abnormal FSH/LH response to GnRH. Hypersecretion of gonadotropins are often associated with pituitary adenomas [DS:H01102] and central precocious puberty [DS:H00937]. Hyposecretion of gonadotropins [DS:H00255 H01700] in premenopausal women leads to absent menstrual cycles, infertility, vaginal dryness, and loss of some female characteristics. In men, this deficiency leads to impotence, atrophy of the testes, decreased sperm production, infertility, and loss of some male characteristics. |
| Category | Endocrine and metabolic disease |
| Network | - |
| Gene | - |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | - |
| Comment | See also H01102 Pituitary adenomas, H00937 Precocious puberty, H00255 Hypogonadotropic hypogonadism, and H01700 Hypopituitarism. |
| Other DBs | ICD-11: 5A61.2 ICD-10: E23.0 MeSH: D006964 D007018 OMIM: 613038 |
| Reference | PMID:6267989 AUTHORS Pierce JG, Parsons TF TITLE Glycoprotein hormones: structure and function. JOURNAL Annu Rev Biochem 50:465-95 (1981) DOI:10.1146/annurev.bi.50.070181.002341 PMID:15684903 AUTHORS Hanberg A TITLE Common disorders of the pituitary gland: hyposecretion versus hypersecretion. JOURNAL J Infus Nurs 28:36-44 (2005) DOI:10.1097/00129804-200501000-00005 PMID:24722134 AUTHORS Ceccato F, Occhi G, Regazzo D, Randi ML, Cecchin D, Gardiman MP, Manara R, Lombardi G, Denaro L, Mantero F, Scaroni C TITLE Gonadotropin secreting pituitary adenoma associated with erythrocytosis: case report and literature review. JOURNAL Hormones (Athens) 13:131-9 (2014) DOI:10.1007/BF03401328 |