H01874 | |
H number | H01874 |
Name | Cronkhite-Canada syndrome |
Description | Cronkhite-Canada syndrome (CCS) is a rare noninherited condition characterized by gastrointestinal hamartomatous polyposis, alopecia, onychodystrophy, hyperpigmentation, and diarrhea. CCS is reported worldwide, with 75% of cases in Japan. The average age of onset is 60 years and the male to female ratio is 3:2. At present, the pathogenesis of CCS is unknown, but the factors that include immune abnormalities, infection, and allergies, may be relevant. There are no evidence-based therapies. Numerous treatments have been attempted in CCS patients, with varying degrees of success. These treatments include glucocorticoids, nutritional support, antibiotics, and polypectomy. |
Category | Digestive system disease |
Network | - |
Gene | - |
Pathogen | - |
Env factor | - |
Carcinogen | - |
Drug | - |
Comment | - |
Other DBs | ICD-11: LD27.01 ICD-10: D13.9 MeSH: D044483 OMIM: 175500 |
Reference | PMID:22675285 AUTHORS Sweetser S, Boardman LA TITLE Cronkhite-Canada syndrome: an acquired condition of gastrointestinal polyposis and dermatologic abnormalities. JOURNAL Gastroenterol Hepatol (N Y) 8:201-3 (2012) PMID:24966624 AUTHORS Wen XH, Wang L, Wang YX, Qian JM TITLE Cronkhite-Canada syndrome: report of six cases and review of literature. JOURNAL World J Gastroenterol 20:7518-22 (2014) DOI:10.3748/wjg.v20.i23.7518 |