| H01905 | |
| H number | H01905 |
| Name | Trichomegaly |
| Description | Eyelash trichomegaly is defined as eyelashes which are found to be of increased length, thickness, and pigmentation. It can be present at birth as part of variety congenital syndromes or as a benign familial trait. Congenital syndromes that include eyelash trichomegaly as a defining diagnostic feature, are Oliver-McFarlane syndrome [DS:H01898] and Cornelia de Lange syndrome [DS:H00631]. It has been identified that mutations in FGF5 underlie the trichomegaly. There are also acquired conditions and drugs that are known to cause eyelash trichomegaly. For example, acquired conditions, such as allergic rhinitis, atopic dermatitis, HIV infection, and certain eye diseases, have commonly been reported to be associated with increased length of the eyelashes. |
| Category | Skin disease |
| Network | - |
| Gene | FGF5 [HSA:2250] [KO:K04358] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | - |
| Comment | See also H01898 PNPLA6-related disorders and H00631 Cornelia de Lange syndrome. |
| Other DBs | ICD-11: LD27.0Y ICD-10: H02.7 OMIM: 190330 |
| Reference | PMID:22607279 AUTHORS Paul LJ, Cohen PR, Kurzrock R TITLE Eyelash trichomegaly: review of congenital, acquired, and drug-associated etiologies for elongation of the eyelashes. JOURNAL Int J Dermatol 51:631-46; quiz 643-4, 646 (2012) DOI:10.1111/j.1365-4632.2011.05315.x PMID:24989505 AUTHORS Higgins CA, Petukhova L, Harel S, Ho YY, Drill E, Shapiro L, Wajid M, Christiano AM TITLE FGF5 is a crucial regulator of hair length in humans. JOURNAL Proc Natl Acad Sci U S A 111:10648-53 (2014) DOI:10.1073/pnas.1402862111 |