| H00008 | |
| H番号 | H00008 |
| 名称 | バーキットリンパ腫 |
| 概要 | Burkitt lymphoma (BL) is a highly aggressive mature B-cell non-Hodgkin's lymphoma consisting of endemic, sporadic, and immunodeficiency-associated variants. Endemic BL (eBL) affects children and young adults in Africa and some other geographical areas and carries Epstein-Barr virus (EBV) in more than 95% of cases. In contrast, sporadic BL (sBL) among adolescents in Europe and North America are mostly EBV-negative. A third type of BL is associated with HIV-infection in adults. All of these subtypes possess chromosomal rearrangements of the c-myc oncogene, the genetic hallmark of BL that contributes to lymphomagenesis through alterations in cell cycle regulation, cellular differentiation, apoptosis, cellular adhesion, and metabolism. Many BL carry point mutation in the p53 tumor suppressor gene or other defects in the p14ARF-MDM2-p53 pathway, and inactivation of the p16INK4a gene by promoter methylation or homozygous deletion. This indicates that disruption of both the pRb and p53 tumor suppressor pathways is critical for BL development. |
| カテゴリ | がん |
| ネットワーク | nt06114(H00008) PI3K signaling (viruses) nt06120(H00008) Calcium signaling (viruses and bacteria) nt06122(H00008) IFN signaling (viruses) nt06123(H00008) TNF signaling (viruses and bacteria) nt06129(H00008) MHC presentation (viruses) nt06130(H00008) Cell cycle (viruses) nt06131(H00008) Apoptosis (viruses and bacteria) nt06133(H00008) RLR signaling (viruses) nt06140(H00008) Transcription (viruses) nt06165 Epstein-Barr virus (EBV) nt06516(H00008) TNF signaling nt06517(H00008) TLR signaling nt06518(H00008) JAK-STAT signaling nt06519(H00008) RLR signaling nt06524(H00008) Apoptosis nt06528(H00008) Calcium signaling nt06530(H00008) PI3K signaling |
| 病因遺伝子 | MYC-IgH (translocation) [HSA:4609] [KO:K04377] p53 (mutation) [HSA:7157] [KO:K04451] p16/INK4A (promoter methylation) [HSA:1029] [KO:K06621] |
| 病原体 | Human herpesvirus 4 (Epstein-Barr virus) [GN:T40079] Human immunodeficiency virus 1 (HIV-1) [GN:T40001] |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | ベタメタゾンリン酸エステルナトリウム [DR:D00972] プレドニゾロン [DR:D00472] メチルプレドニゾロンコハク酸エステルナトリウム [DR:D00751] イホスファミド [DR:D00343] ブスルファン [DR:D00248] メルファラン [DR:D00369] ニムスチン塩酸塩 [DR:D01059] ラニムスチン [DR:D01760] シタラビン [DR:D00168] ゲムシタビン塩酸塩 [DR:D01155] フルダラビンリン酸エステル [DR:D01907] ブレオマイシン塩酸塩 [DR:D03229] ペプロマイシン硫酸塩 [DR:D02063] ドキソルビシン塩酸塩 [DR:D01275] エピルビシン塩酸塩 [DR:D02214] アクラルビシン塩酸塩 [DR:D01911] ピラルビシン塩酸塩 [DR:D08386] ビンブラスチン硫酸塩 [DR:D01068] ビンデシン硫酸塩 [DR:D01769] エトポシド [DR:D00125] ミトキサントロン塩酸塩 [DR:D02166] リツキシマブ [DR:D02994] (CD20陽性) シスプラチン [DR:D00275] カルボプラチン [DR:D01363] L-アスパラギナーゼ [DR:D02997] ソブゾキサン [DR:D01404] クリサンタスパーゼ [DR:D10517] |
| コメント | - |
| リンク | ICD-11: 2A85.6 ICD-10: C83.7 MeSH: D002051 |
| 文献 | PMID:12191637 著者 Lindstrom MS, Wiman KG. タイトル Role of genetic and epigenetic changes in Burkitt lymphoma. 雑誌 Semin Cancer Biol 12:381-7 (2002) DOI:10.1016/S1044-579X(02)00058-5 PMID:15803153 著者 Kuppers R. タイトル Mechanisms of B-cell lymphoma pathogenesis. 雑誌 Nat Rev Cancer 5:251-62 (2005) DOI:10.1038/nrc1589 PMID:16062089 著者 Patel P, Moazzam N, Potti A, Mehdi SA. タイトル Azathioprine induced hodgkin lymphoma: a case report and review of literature. 雑誌 Am J Clin Oncol 28:427-8 (2005) DOI:10.1097/01.coc.0000168670.28659.8d PMID:15760280 著者 Schottenfeld D, Beebe-Dimmer JL. タイトル Advances in cancer epidemiology: understanding causal mechanisms and the evidence for implementing interventions. 雑誌 Annu Rev Public Health 26:37-60 (2005) DOI:10.1146/annurev.publhealth.26.021304.144402 PMID:15660110 著者 Luch A. タイトル Nature and nurture - lessons from chemical carcinogenesis. 雑誌 Nat Rev Cancer 5:113-25 (2005) DOI:10.1038/nrc1546 PMID:12464351 著者 Kolman A, Chovanec M, Osterman-Golkar S. タイトル Genotoxic effects of ethylene oxide, propylene oxide and epichlorohydrin in humans: update review (1990-2001). 雑誌 Mutat Res 512:173-94 (2002) DOI:10.1016/S1383-5742(02)00067-4 PMID:17530489 著者 Abnet CC. タイトル Carcinogenic food contaminants. 雑誌 Cancer Invest 25:189-96 (2007) DOI:10.1080/07357900701208733 |