| H00013 | |
| H番号 | H00013 |
| 名称 | 小細胞肺癌 |
| 概要 | Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% of all lung cancer cases. Molecular mechanisms altered in SCLC include induced expression of oncogene, MYC, and loss of tumorsuppressor genes, such as p53, PTEN, RB, and FHIT. The overexpression of MYC proteins in SCLC is largely a result of gene amplification. Such overexpression leads to more rapid proliferation and loss of terminal differentiation. Mutation or deletion of p53 or PTEN can lead to more rapid proliferation and reduced apoptosis. The retinoblastoma gene RB1 encodes a nuclear phosphoprotein that helps to regulate cell-cycle progression. The fragile histidine triad gene FHIT encodes the enzyme diadenosine triphosphate hydrolase, which is thought to have an indirect role in proapoptosis and cell-cycle control. |
| カテゴリ | がん 疾患パスウェイ hsa05222 小細胞肺癌 |
| ネットワーク | nt06267 Small cell lung cancer nt06512(H00013) Chromosome cohesion and segregation nt06524(H00013) Apoptosis |
| 病因遺伝子 | MYC (amplification) [HSA:4609] [KO:K04377] BCL2 (overexpression) [HSA:596] [KO:K02161] FHIT [HSA:2272] [KO:K01522] TP53 [HSA:7157] [KO:K04451] RB1 [HSA:5925] [KO:K06618] PTEN [HSA:5728] [KO:K01110] PPP2R1B [HSA:5519] [KO:K03456] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | マイトマイシンC [DR:D00208] シクロホスファミド水和物 [DR:D00287] イホスファミド [DR:D00343] ニムスチン塩酸塩 [DR:D01059] フルオロウラシル [DR:D00584] シタラビン [DR:D00168] テガフール・ウラシル [DR:D02131] ブレオマイシン塩酸塩 [DR:D03229] ドキソルビシン塩酸塩 [DR:D01275] アクラルビシン塩酸塩 [DR:D01911] アムルビシン塩酸塩 [DR:D07100] ビンデシン硫酸塩 [DR:D01769] エトポシド [DR:D00125] ノギテカン塩酸塩 [DR:D02168] イリノテカン塩酸塩水和物 [DR:D01061] デュルバルマブ [DR:D10808] アテゾリズマブ [DR:D10773] シスプラチン [DR:D00275] カルボプラチン [DR:D01363] ネダプラチン [DR:D01416] タラポルフィンナトリウム [DR:D01985] ストレプトコックス・ピオゲネス（A群3型）Su株ペニシリン処理凍結乾燥粉末 [DR:D08756] |
| コメント | - |
| リンク | ICD-11: 2C25.1 ICD-10: C34 MeSH: D055752 |
| 文献 | PMID:12741677 著者 Yokota J, Nishioka M, Tani M, Kohno T. タイトル Genetic alterations responsible for metastatic phenotypes of lung cancer cells. 雑誌 Clin Exp Metastasis 20:189-93 (2003) DOI:10.1023/a:1022978932215 PMID:12711111 著者 Sanchez-Cespedes M. タイトル Dissecting the genetic alterations involved in lung carcinogenesis. 雑誌 Lung Cancer 40:111-21 (2003) DOI:10.1016/S0169-5002(03)00033-3 PMID:12407699 著者 Mitsuuchi Y, Testa JR. タイトル Cytogenetics and molecular genetics of lung cancer. 雑誌 Am J Med Genet 115:183-8 (2002) DOI:10.1002/ajmg.10692 PMID:16112428 著者 Panani AD, Roussos C. タイトル Cytogenetic and molecular aspects of lung cancer. 雑誌 Cancer Lett 239:1-9 (2006) DOI:10.1016/j.canlet.2005.06.030 PMID:2983887 (MYC amplification) 著者 Saksela K, Bergh J, Lehto VP, Nilsson K, Alitalo K タイトル Amplification of the c-myc oncogene in a subpopulation of human small cell lung cancer. 雑誌 Cancer Res 45:1823-7 (1985) PMID:17426248 (BCL2 overexpression) 著者 Olejniczak ET, Van Sant C, Anderson MG, Wang G, Tahir SK, Sauter G, Lesniewski R, Semizarov D タイトル Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains. 雑誌 Mol Cancer Res 5:331-9 (2007) DOI:10.1158/1541-7786.MCR-06-0367 PMID:8620533 (FHIT) 著者 Sozzi G, Veronese ML, Negrini M, Baffa R, Cotticelli MG, Inoue H, Tornielli S, Pilotti S, De Gregorio L, Pastorino U, Pierotti MA, Ohta M, Huebner K, Croce CM タイトル The FHIT gene 3p14.2 is abnormal in lung cancer. 雑誌 Cell 85:17-26 (1996) DOI:10.1016/s0092-8674(00)81078-8 PMID:2554494 (TP53) 著者 Takahashi T, Nau MM, Chiba I, Birrer MJ, Rosenberg RK, Vinocour M, Levitt M, Pass H, Gazdar AF, Minna JD タイトル p53: a frequent target for genetic abnormalities in lung cancer. 雑誌 Science 246:491-4 (1989) DOI:10.1126/science.2554494 PMID:2594029 (RB1) 著者 Yandell DW, Campbell TA, Dayton SH, Petersen R, Walton D, Little JB, McConkie-Rosell A, Buckley EG, Dryja TP タイトル Oncogenic point mutations in the human retinoblastoma gene: their application to genetic counseling. 雑誌 N Engl J Med 321:1689-95 (1989) DOI:10.1056/NEJM198912213212501 PMID:9696041 (PTEN) 著者 Yokomizo A, Tindall DJ, Drabkin H, Gemmill R, Franklin W, Yang P, Sugio K, Smith DI, Liu W タイトル PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers. 雑誌 Oncogene 17:475-9 (1998) DOI:10.1038/sj.onc.1201956 PMID:9765152 (PPP2R1B) 著者 Wang SS, Esplin ED, Li JL, Huang L, Gazdar A, Minna J, Evans GA タイトル Alterations of the PPP2R1B gene in human lung and colon cancer. 雑誌 Science 282:284-7 (1998) DOI:10.1126/science.282.5387.284 |