| H00015 | |
| H番号 | H00015 |
| 名称 | 悪性胸膜中皮腫 |
| 概要 | Malignant mesothelioma (MM) is a rare but very aggressive tumor that arises from mesothelial cells lining the pleural, peritoneal and pericardial cavities. Malignant pleural mesothelioma (MPM) is the most common type, accounting for about 70% of all MM cases. Past asbestos exposure represents the major risk factor for MPM, as the link between asbestos fibres and MPM has been largely proved by epidemiological and experimental studies. Recently, simian virus 40 (SV40) has been implicated in the aetiology of MPM. The accumulation of numerous clonal chromosomal deletions in most MMs suggests a multistep process of tumorigenesis, characterized by the loss and/or inactivation of multiple tumor suppressor genes (TSGs). Cytogenetic and loss of heterozygosity (LOH) analyses of MMs have demonstrated frequent deletions of specific sites within chromosome arms 1p, 3p, 6q, 9p, 13q, 15q, and 22q. Furthermore, TSGs within two of these regions, i.e., p16/CDKN2A-p14ARF at 9p21 and NF2 at 22q12, are frequently altered in MMs. Mutations of the p53 gene (TP53) are occasionally observed in MMs. |
| カテゴリ | がん |
| ネットワーク | - |
| 病因遺伝子 | p53 (inactivation) [HSA:7157] [KO:K04451] p16/CDKN2A (deletion) [HSA:1029] [KO:K06621] p15/CDKN2B (deletion) [HSA:1030] [KO:K04685] NF2 (mutation) [HSA:4771] [KO:K16684] PDGF-A (overexpression) [HSA:5154] [KO:K04359] PDGF-B (overexpression) [HSA:5155] [KO:K17386] IGF-1 (expression) [HSA:3479] [KO:K05459] IGF-R1 (expression) [HSA:3480] [KO:K05087] |
| 病原体 | Simian virus 40 (SV40) [GN:T40086] |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | ペメトレキセドナトリウム水和物 [DR:D06503] ペメトレキセドナトリウムヘミペンタ水和物 [DR:D10596] ニボルマブ [DR:D10316] イピリムマブ [DR:D04603] シスプラチン [DR:D00275] |
| コメント | - |
| リンク | ICD-11: 2C26 ICD-10: C45 MeSH: D008654 |
| 文献 | PMID:16216411 著者 Whitson BA, Kratzke RA. タイトル Molecular pathways in malignant pleural mesothelioma. 雑誌 Cancer Lett 239:183-9 (2006) DOI:10.1016/j.canlet.2005.08.010 PMID:15691231 著者 Jaurand MC, Fleury-Feith J. タイトル Pathogenesis of malignant pleural mesothelioma. 雑誌 Respirology 10:2-8 (2005) DOI:10.1111/j.1440-1843.2005.00694.x PMID:15660110 著者 Luch A. タイトル Nature and nurture - lessons from chemical carcinogenesis. 雑誌 Nat Rev Cancer 5:113-25 (2005) DOI:10.1038/nrc1546 PMID:17375514 著者 O'Reilly KM, Mclaughlin AM, Beckett WS, Sime PJ. タイトル Asbestos-related lung disease. 雑誌 Am Fam Physician 75:683-8 (2007) PMID:15955137 著者 Sterman DH, Albelda SM. タイトル Advances in the diagnosis, evaluation, and management of malignant pleural mesothelioma. 雑誌 Respirology 10:266-83 (2005) DOI:10.1111/j.1440-1843.2005.00714.x PMID:12883236 著者 Ordonez NG. タイトル The immunohistochemical diagnosis of mesothelioma: a comparative study of epithelioid mesothelioma and lung adenocarcinoma. 雑誌 Am J Surg Pathol 27:1031-51 (2003) DOI:10.1097/00000478-200308000-00001 |