| H00027 | |
| H番号 | H00027 |
| 名称 | 卵巣癌 |
| 概要 | Ovarian cancer is the sixth most common cancer and the fifth leading cause of cancer-related death among women in developed countries. Approximately 90% of human ovarian cancer arises within the ovarian surface epithelium (OSE), with the rest originating from granulosa cells or, rarely, stroma or germ cells. Ovarian epithelial tumors are divided into mucinous, serous, endometrioid, and clear cell subtypes. Approximately 10% of ovarian cancers arise in women who have inherited mutations in cancer susceptibility genes (BRCA1 or BRCA2). The vast majority of ovarian cancers are sporadic, resulting from the accumulation of genetic damage over a lifetime. Several specific genes involved in ovarian carcinogenesis have been identified, including the p53 tumor suppressor gene and ERBB2 and PIK3CA oncogenes. |
| カテゴリ | がん |
| ネットワーク | - |
| 病因遺伝子 | BRCA1 (germline mutation / deletion) [HSA:672] [KO:K10605] BRCA2 (germline mutation / deletion) [HSA:675] [KO:K08775] MSH2 (germline mutation) [HSA:4436] [KO:K08735] MLH1 (germline mutation) [HSA:4292] [KO:K08734] ERBB2 (amplification / overexpression) [HSA:2064] [KO:K05083] K-ras (mutation) [HSA:3845] [KO:K07827] AKT2 (amplification) [HSA:208] [KO:K04456] PIK3CA (amplification) [HSA:5290] [KO:K00922] c-MYC (overexpression) [HSA:4609] [KO:K04377] p53 (mutation / deletion, overexpression) [HSA:7157] [KO:K04451] CTNNB1 [HSA:1499] [KO:K02105] PRKN [HSA:5071] [KO:K04556] OPCML [HSA:4978] [KO:K06773] AKT1 [HSA:207] [KO:K04456] CDH1 [HSA:999] [KO:K05689] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | シクロホスファミド水和物 [DR:D00287] イホスファミド [DR:D00343] フルオロウラシル [DR:D00584] ゲムシタビン塩酸塩 [DR:D01155] ブレオマイシン塩酸塩 [DR:D03229] ドキソルビシン塩酸塩 [DR:D01275] エピルビシン塩酸塩 [DR:D02214] アクラルビシン塩酸塩 [DR:D01911] ピラルビシン塩酸塩 [DR:D08386] ビンブラスチン硫酸塩 [DR:D01068] エトポシド [DR:D00125] パクリタキセル [DR:D00491] ドセタキセル水和物 [DR:D02165] ドセタキセル [DR:D07866] ノギテカン塩酸塩 [DR:D02168] イリノテカン塩酸塩水和物 [DR:D01061] ベバシズマブ [DR:D06409] シスプラチン [DR:D00275] カルボプラチン [DR:D01363] オラパリブ [DR:D09730] (相同組換え修復欠損を有する) ニラパリブトシル酸塩水和物 [DR:D11895] (gBRCA変異陽性) ネダプラチン [DR:D01416] |
| コメント | - |
| リンク | ICD-11: 2C73 ICD-10: C56 MeSH: D010051 OMIM: 167000 |
| 文献 | PMID:15111296 著者 Shih IeM, Kurman RJ. タイトル Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis. 雑誌 Am J Pathol 164:1511-8 (2004) DOI:10.1016/S0002-9440(10)63708-X PMID:12886939 著者 Katabuchi H, Okamura H. タイトル Cell biology of human ovarian surface epithelial cells and ovarian carcinogenesis. 雑誌 Med Electron Microsc 36:74-86 (2003) DOI:10.1007/s00795-002-0196-6 PMID:12413930 著者 Wenham RM, Lancaster JM, Berchuck A. タイトル Molecular aspects of ovarian cancer. 雑誌 Best Pract Res Clin Obstet Gynaecol 16:483-97 (2002) DOI:10.1053/beog.2002.0298 PMID:10417756 著者 Wright K, Wilson P, Morland S, Campbell I, Walsh M, Hurst T, Ward B, Cummings M, Chenevix-Trench G タイトル beta-catenin mutation and expression analysis in ovarian cancer: exon 3 mutations and nuclear translocation in 16% of endometrioid tumours. 雑誌 Int J Cancer 82:625-9 (1999) DOI:10.1002/(sici)1097-0215(19990827)82:5<625::aid-ijc1>3.0.co;2-2 PMID:14614460 著者 Denison SR, Wang F, Becker NA, Schule B, Kock N, Phillips LA, Klein C, Smith DI タイトル Alterations in the common fragile site gene Parkin in ovarian and other cancers. 雑誌 Oncogene 22:8370-8 (2003) DOI:10.1038/sj.onc.1207072 PMID:22585860 著者 McKie AB, Vaughan S, Zanini E, Okon IS, Louis L, de Sousa C, Greene MI, Wang Q, Agarwal R, Shaposhnikov D, Wong JL, Gungor H, Janczar S, El-Bahrawy M, Lam EW, Chayen NE, Gabra H タイトル The OPCML tumor suppressor functions as a cell surface repressor-adaptor, negatively regulating receptor tyrosine kinases in epithelial ovarian cancer. 雑誌 Cancer Discov 2:156-71 (2012) DOI:10.1158/2159-8290.CD-11-0256 PMID:17611497 著者 Carpten JD, Faber AL, Horn C, Donoho GP, Briggs SL, Robbins CM, Hostetter G, Boguslawski S, Moses TY, Savage S, Uhlik M, Lin A, Du J, Qian YW, Zeckner DJ, Tucker-Kellogg G, Touchman J, Patel K, Mousses S, Bittner M, Schevitz R, Lai MH, Blanchard KL, Thomas JE タイトル A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. 雑誌 Nature 448:439-44 (2007) DOI:10.1038/nature05933 PMID:18026186 著者 Blechschmidt K, Sassen S, Schmalfeldt B, Schuster T, Hofler H, Becker KF タイトル The E-cadherin repressor Snail is associated with lower overall survival of ovarian cancer patients. 雑誌 Br J Cancer 98:489-95 (2008) DOI:10.1038/sj.bjc.6604115 |