| H00032 | |
| H番号 | H00032 |
| 名称 | 甲状腺癌 |
| 概要 | Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cells. Their behavior varies from the indolent growing, well-differentiated papillary and follicular carcinomas (PTC and FTC, respectively) to the extremely aggressive undifferentiated carcinoma (UC). Somatic rearrangements of RET and TRK are almost exclusively found in PTC and may be found in early stages. The most distinctive molecular features of FTC are the prominence of aneuploidy and the high prevalence of RAS mutations and PAX8-PPAR{gamma} rearrangements. p53 seems to play a crucial role in the dedifferentiation process of thyroid carcinoma. |
| カテゴリ | がん 疾患パスウェイ hsa05216 甲状腺癌 |
| ネットワーク | nt06274 Thyroid cancer nt06530(H00032) PI3K signaling |
| 病因遺伝子 | RET/CCDC6 (rearrangement) [HSA:5979 8030] [KO:K05126 K09288] RET/NCOA4 (rearrangement) [HSA:5979 8031] [KO:K05126 K09289] TPM3/NTRK1 (rearrangement) [HSA:4914 7170] [KO:K03176 K09290] TPR/NTRK1 (rearrangement) [HSA:7175 7170] [KO:K09291 K09290] TFG/NTRK1 (rearrangement) [HSA:10342 7170] [KO:K09292 K09290] PAX8/PPARG (rearrangement) [HSA:7849 5468] [KO:K09293 K08530] KRAS [HSA:3845] [KO:K07827] HRAS [HSA:3265] [KO:K02833] NRAS [HSA:4893] [KO:K07828] BRAF [HSA:673] [KO:K04365] CTNNB1 [HSA:1499] [KO:K02105] TP53 [HSA:7157] [KO:K04451] CDH1 [HSA:999] [KO:K05689] MINPP1 [HSA:9562] [KO:K03103] (NMTC1) NKX2-1 [HSA:7080] [KO:K09342] (NMTC2) SRGAP1 [HSA:57522] [KO:K07526] (NMTC4) FOXE1 [HSA:2304] [KO:K09398] (NMTC5) HABP2 [HSA:3026] [KO:K08648] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | ブレオマイシン塩酸塩 [DR:D03229] ソラフェニブトシル酸塩 [DR:D06272] レンバチニブメシル酸塩 [DR:D09920] セルペルカチニブ [DR:D11713] (RET融合遺伝子陽性) ストレプトコックス・ピオゲネス（A群3型）Su株ペニシリン処理凍結乾燥粉末 [DR:D08756] ヨウ化ナトリウム (131I) [DR:D02259] |
| コメント | - |
| リンク | ICD-11: 2D10 ICD-10: C73 MeSH: D013964 OMIM: 188550 188470 616534 616535 |
| 文献 | PMID:11165748 著者 Gimm O. タイトル Thyroid cancer. 雑誌 Cancer Lett 163:143-56 (2001) DOI:10.1016/S0304-3835(00)00697-2 PMID:16557281 (RET/CCDC6, TPM3/NTRK1, TPR/NTRK1, TFG/NTRK1, BRAF, CTNNB1, TP53, CDH1) 著者 Kondo T, Ezzat S, Asa SL. タイトル Pathogenetic mechanisms in thyroid follicular-cell neoplasia. 雑誌 Nat Rev Cancer 6:292-306 (2006) DOI:10.1038/nrc1836 PMID:16189702 (RET/CCDC6, RET/NCOA4, PAX8/PPARG, KRAS, HRAS, NRAS) 著者 Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P. タイトル Molecular pathology of well-differentiated thyroid carcinomas. 雑誌 Virchows Arch 447:787-93 (2005) DOI:10.1007/s00428-005-0065-5 PMID:11297621 (MINPP1) 著者 Gimm O, Chi H, Dahia PL, Perren A, Hinze R, Komminoth P, Dralle H, Reynolds PR, Eng C タイトル Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas. 雑誌 J Clin Endocrinol Metab 86:1801-5 (2001) DOI:10.1210/jcem.86.4.7419 PMID:19176457 (NMTC1) 著者 Ngan ES, Lang BH, Liu T, Shum CK, So MT, Lau DK, Leon TY, Cherny SS, Tsai SY, Lo CY, Khoo US, Tam PK, Garcia-Barcelo MM タイトル A germline mutation (A339V) in thyroid transcription factor-1 (TITF-1/NKX2.1) in patients with multinodular goiter and papillary thyroid carcinoma. 雑誌 J Natl Cancer Inst 101:162-75 (2009) DOI:10.1093/jnci/djn471 PMID:23539728 (NMTC2) 著者 He H, Bronisz A, Liyanarachchi S, Nagy R, Li W, Huang Y, Akagi K, Saji M, Kula D, Wojcicka A, Sebastian N, Wen B, Puch Z, Kalemba M, Stachlewska E, Czetwertynska M, Dlugosinska J, Dymecka K, Ploski R, Krawczyk M, Morrison PJ, Ringel MD, Kloos RT, Jazdzewski K, Symer DE, Vieland VJ, Ostrowski M, Jarzab B, de la Chapelle A タイトル SRGAP1 is a candidate gene for papillary thyroid carcinoma susceptibility. 雑誌 J Clin Endocrinol Metab 98:E973-80 (2013) DOI:10.1210/jc.2012-3823 PMID:25381600 (NMTC4) 著者 Pereira JS, da Silva JG, Tomaz RA, Pinto AE, Bugalho MJ, Leite V, Cavaco BM タイトル Identification of a novel germline FOXE1 variant in patients with familial non-medullary thyroid carcinoma (FNMTC). 雑誌 Endocrine 49:204-14 (2015) DOI:10.1007/s12020-014-0470-0 PMID:26222560 (NMTC5) 著者 Gara SK, Jia L, Merino MJ, Agarwal SK, Zhang L, Cam M, Patel D, Kebebew E タイトル Germline HABP2 Mutation Causing Familial Nonmedullary Thyroid Cancer. 雑誌 N Engl J Med 373:448-55 (2015) DOI:10.1056/NEJMoa1502449 |