| H00342 | |
| H番号 | H00342 |
| 名称 | 結核 |
| 概要 | Tuberculosis is an infectious disease caused by strains of mycobacteria, mainly Mycobacterium tuberculosis, resulting in an estimated two million deaths each year worldwide, more than from any other single bacterial pathogen. Inhalation is the predominant pathway of infection, making pulmonary tuberculosis the most common form of tuberculosis. Tuberculosis may arise either from a recent infection with M. tuberculosis, or from the reactivation of dormant bacilli, years or decades after initial infection. Extrapulmonary tuberculosis mainly results from reactivation of a tuberculous focus after hematogenous dissemination or lymphogenous spread from a primary, usually pulmonary focus. |
| カテゴリ | 細菌感染症 疾患パスウェイ hsa05152 結核 |
| ネットワーク | nt06517(H00342) TLR signaling |
| 病因遺伝子 | IFNG (protection) [HSA:3458] [KO:K04687] IFNGR1 (susceptibility/protection) [HSA:3459] [KO:K05132] IFNGR2 [HSA:3460] [KO:K05133] HLA-DRB1 (susceptibility) [HSA:3123] [KO:K06752] HLA-DQB1 (susceptibility) [HSA:3119] [KO:K06752] SLC11A1 (susceptibility) [HSA:6556] [KO:K12347] VDR (susceptibility) [HSA:7421] [KO:K08539] MBL2 (protection) [HSA:4153] [KO:K03991] CCL2 (susceptibility) [HSA:6347] [KO:K14624] CD209 (susceptibility) [HSA:30835] [KO:K06563] CISH (susceptibility) [HSA:1154] [KO:K04701] IRGM (protection) [HSA:345611] [KO:K14139] SP110 (susceptibility) [HSA:3431] [KO:K24503] TIRAP (protection) [HSA:114609] [KO:K05403] TLR2 (susceptibility) [HSA:7097] [KO:K10159] |
| 病原体 | Mycobacterium tuberculosis [GN:mtu mtc mtf mtb mtk mtg mti mte mtl mto mtd mtj mtuc mtue mtuh maf] Mycobacterium canettii [GN:mce mcq mcv mcx mcz] |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | デキサメタゾン [DR:D00292] レボフロキサシン水和物 [DR:D00588] フドステイン [DR:D01845] ヒドロコルチゾン [DR:D00088] コルチゾン酢酸エステル [DR:D00973] ベタメタゾン [DR:D00244] プレドニゾロン [DR:D00472] 柴胡桂枝湯エキス [DR:D06964] ストレプトマイシン硫酸塩 [DR:D01350] サイクロセリン [DR:D00877] リファンピシン [DR:D00211] エンビオマイシン硫酸塩 [DR:D03278] カナマイシン硫酸塩 [DR:D03262] リファブチン [DR:D00424] パラアミノサリチル酸カルシウム水和物 [DR:D03368] アルミノパラアミノサリチル酸カルシウム水和物 [DR:D01643] イソニアジド [DR:D00346] イソニアジドメタンスルホン酸ナトリウム水和物 [DR:D02002] ピラジナミド [DR:D00144] エチオナミド [DR:D00591] エタンブトール塩酸塩 [DR:D00878] 乾燥BCGワクチン [DR:D06466] |
| コメント | - |
| リンク | ICD-11: 1B10 1B11 1B12 ICD-10: A15 A16 A17 A18 A19 MeSH: D014376 MedlinePlus: 000077 OMIM: 607948 |
| 文献 | PMID:20206579 著者 Moller M, Hoal EG タイトル Current findings, challenges and novel approaches in human genetic susceptibility to tuberculosis. 雑誌 Tuberculosis (Edinb) 90:71-83 (2010) DOI:10.1016/j.tube.2010.02.002 PMID:17147011 著者 De Backer AI, Mortele KJ, De Keulenaer BL, Parizel PM タイトル Tuberculosis: epidemiology, manifestations, and the value of medical imaging in diagnosis. 雑誌 JBR-BTR 89:243-50 (2006) PMID:21420161 著者 Lawn SD, Zumla AI タイトル Tuberculosis. 雑誌 Lancet 378:57-72 (2011) DOI:10.1016/S0140-6736(10)62173-3 PMID:16690980 (IFNG IFNGR1 IFNGR2) 著者 Cooke GS, Campbell SJ, Sillah J, Gustafson P, Bah B, Sirugo G, Bennett S, McAdam KP, Sow O, Lienhardt C, Hill AV タイトル Polymorphism within the interferon-gamma/receptor complex is associated with pulmonary tuberculosis. 雑誌 Am J Respir Crit Care Med 174:339-43 (2006) DOI:10.1164/rccm.200601-088OC PMID:24024195 (SLC11A1 VDR HLA-DRB1 HLA-DQB1) 著者 Wu F, Zhang W, Zhang L, Wu J, Li C, Meng X, Wang X, He P, Zhang J タイトル NRAMP1, VDR, HLA-DRB1, and HLA-DQB1 gene polymorphisms in susceptibility to tuberculosis among the Chinese Kazakh population: a case-control study. 雑誌 Biomed Res Int 2013:484535 (2013) DOI:10.1155/2013/484535 PMID:16103355 (SLC11A1) 著者 Malik S, Abel L, Tooker H, Poon A, Simkin L, Girard M, Adams GJ, Starke JR, Smith KC, Graviss EA, Musser JM, Schurr E タイトル Alleles of the NRAMP1 gene are risk factors for pediatric tuberculosis disease. 雑誌 Proc Natl Acad Sci U S A 102:12183-8 (2005) DOI:10.1073/pnas.0503368102 PMID:32847384 (VDR) 著者 Maruthai K, Sankar S, Subramanian M タイトル Methylation Status of VDR Gene and its Association with Vitamin D Status and VDR Gene Expression in Pediatric Tuberculosis Disease. 雑誌 Immunol Invest 51:73-87 (2022) DOI:10.1080/08820139.2020.1810702 PMID:33270011 (MBL2) 著者 Taheri M, Karimloo R, Sarani H, Molashahi B, Naderi M, Bahari G, Hashemi M タイトル Association Study of MBL2 Gene Polymorphisms and Risk of Tuberculosis in Southeast of Iran. 雑誌 Prague Med Rep 121:236-243 (2020) DOI:10.14712/23362936.2020.20 PMID:20041183 (CCL2) 著者 Hasan Z, Cliff JM, Dockrell HM, Jamil B, Irfan M, Ashraf M, Hussain R タイトル CCL2 responses to Mycobacterium tuberculosis are associated with disease severity in tuberculosis. 雑誌 PLoS One 4:e8459 (2009) DOI:10.1371/journal.pone.0008459 PMID:16379498 (CD209) 著者 Barreiro LB, Neyrolles O, Babb CL, Tailleux L, Quach H, McElreavey K, Helden PD, Hoal EG, Gicquel B, Quintana-Murci L タイトル Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis. 雑誌 PLoS Med 3:e20 (2006) DOI:10.1371/journal.pmed.0030020 PMID:28954234 (CISH) 著者 Queval CJ, Song OR, Carralot JP, Saliou JM, Bongiovanni A, Deloison G, Deboosere N, Jouny S, Iantomasi R, Delorme V, Debrie AS, Park SJ, Gouveia JC, Tomavo S, Brosch R, Yoshimura A, Yeramian E, Brodin P タイトル Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling. 雑誌 Cell Rep 20:3188-3198 (2017) DOI:10.1016/j.celrep.2017.08.101 PMID:19750224 (IRGM) 著者 Intemann CD, Thye T, Niemann S, Browne EN, Amanua Chinbuah M, Enimil A, Gyapong J, Osei I, Owusu-Dabo E, Helm S, Rusch-Gerdes S, Horstmann RD, Meyer CG タイトル Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains. 雑誌 PLoS Pathog 5:e1000577 (2009) DOI:10.1371/journal.ppat.1000577 PMID:17149599 (SP110) 著者 Szeszko JS, Healy B, Stevens H, Balabanova Y, Drobniewski F, Todd JA, Nejentsev S タイトル Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis. 雑誌 Hum Genet 121:155-60 (2007) DOI:10.1007/s00439-006-0293-z PMID:18305471 (TIRAP) 著者 Nejentsev S, Thye T, Szeszko JS, Stevens H, Balabanova Y, Chinbuah AM, Hibberd M, van de Vosse E, Alisjahbana B, van Crevel R, Ottenhoff TH, Png E, Drobniewski F, Todd JA, Seielstad M, Horstmann RD タイトル Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations. 雑誌 Nat Genet 40:261-2; author reply 262-3 (2008) DOI:10.1038/ng0308-261 PMID:14979495 (TLR2) 著者 Ogus AC, Yoldas B, Ozdemir T, Uguz A, Olcen S, Keser I, Coskun M, Cilli A, Yegin O タイトル The Arg753GLn polymorphism of the human toll-like receptor 2 gene in tuberculosis disease. 雑誌 Eur Respir J 23:219-23 (2004) DOI:10.1183/09031936.03.00061703 |