| H00361 | |
| H番号 | H00361 |
| 名称 | マラリア |
| 概要 | Malaria, the most common parasitic disease in the world, is caused by Plasmodium parasites that are transmitted by female Anopheline mosquitoes. Plasmodium infections result in a spectrum of clinical effects, including asymptomatic parasitemia, severe malaria, and death. Most severe cases occur in sub-Saharan Africa. In severe malaria, complications such as anemia, respiratory distress, renal failure, and cerebral malaria are observed in addition to cyclical fevers. |
| カテゴリ | 寄生虫感染症 疾患パスウェイ hsa05144 マラリア |
| ネットワーク | - |
| 病因遺伝子 | ACKR1 (protection) [HSA:2532] [KO:K06574] CD36 (susceptibility/reduced risk) [HSA:948] [KO:K06259] CISH (susceptibility) [HSA:1154] [KO:K04701] CR1 (resistance) [HSA:1378] [KO:K04011] FCGR2A (susceptibility) [HSA:2212] [KO:K06472] FCGR2B (resistance) [HSA:2213] [KO:K12560] G6PD (resistance) [HSA:2539] [KO:K00036] GYPA (resistance) [HSA:2993] [KO:K06575] GYPB (resistance) [HSA:2994] [KO:K20925] GYPC (resistance) [HSA:2995] [KO:K06576] HBB (resistance) [HSA:3043] [KO:K13823] ICAM1 (susceptibility) [HSA:3383] [KO:K06490] NOS2 (resistance) [HSA:4843] [KO:K13241] SLC4A1 (resistance) [HSA:6521] [KO:K06573] TIRAP (protection) [HSA:114609] [KO:K05403] TNF (susceptibility) [HSA:7124] [KO:K03156] |
| 病原体 | Plasmodium falciparum [GN:pfa pfd pfh] (Falciparum malaria) Plasmodium vivax [GN:pvx] (Vivax malaria) Plasmodium knowlesi H [GN:pkn] Plasmodium malariae Plasmodium ovale |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | プリマキンリン酸塩 [DR:D02126] アトバコン・プログアニル塩酸塩 [DR:D02472] メフロキン塩酸塩 [DR:D00831] アルテメテル・ルメファントリン [DR:D02484] |
| コメント | Vector: Anopheles gambiae (African malaria mosquito) [GN:aga] |
| リンク | ICD-11: 1F40 1F41 1F42 1F43 ICD-10: B50 B51 B52 B53 MeSH: D008288 MedlinePlus: 000621 OMIM: 611162 |
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