| H00932 | |
| H番号 | H00932 |
| 名称 | 石灰沈着性膵炎 |
| 概要 | Tropical calcific pancreatitis (TCP) is a subtype of chronic pancreatitis unique to developing countries in tropical regions. Patients present with recurrent abdominal pain, nutritional deficiencies, and insulin-requiring diabetes resulting from chronic pancreatitis before age 30. Several environmental and genetic factors are implicated in TCP. |
| カテゴリ | 消化器系疾患 |
| ネットワーク | - |
| 病因遺伝子 | SPINK1 [HSA:6690] [KO:K23417] CTRC [HSA:11330] [KO:K01311] CTSB [HSA:1508] [KO:K01363] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | - |
| コメント | - |
| リンク | ICD-11: DC32.5 MeSH: C564276 OMIM: 608189 |
| 文献 | PMID:18604651 著者 Witt H, Bhatia E タイトル Genetic aspects of tropical calcific pancreatitis. 雑誌 Rev Endocr Metab Disord 9:213-26 (2008) DOI:10.1007/s11154-008-9088-y PMID:21323990 著者 Reddy DN, Prasad SS タイトル Genetic basis of chronic pancreatitis in Asia Pacific region. 雑誌 J Gastroenterol Hepatol 26 Suppl 2:2-5 (2011) DOI:10.1111/j.1440-1746.2010.06598.x PMID:12011155 (SPINK1) 著者 Chandak GR, Idris MM, Reddy DN, Bhaskar S, Sriram PV, Singh L タイトル Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis. 雑誌 J Med Genet 39:347-51 (2002) DOI:10.1136/jmg.39.5.347 PMID:18059268 (CTRC) 著者 Rosendahl J, Witt H, Szmola R, Bhatia E, Ozsvari B, Landt O, Schulz HU, Gress TM, Pfutzer R, Lohr M, Kovacs P, Bluher M, Stumvoll M, Choudhuri G, Hegyi P, te Morsche RH, Drenth JP, Truninger K, Macek M Jr, Puhl G, Witt U, Schmidt H, Buning C, Ockenga J, Kage A, Groneberg DA, Nickel R, Berg T, Wiedenmann B, Bodeker H, Keim V, Mossner J, Teich N, Sahin-Toth M タイトル Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis. 雑誌 Nat Genet 40:78-82 (2008) DOI:10.1038/ng.2007.44 PMID:16492714 (CTSB) 著者 Mahurkar S, Idris MM, Reddy DN, Bhaskar S, Rao GV, Thomas V, Singh L, Chandak GR タイトル Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis. 雑誌 Gut 55:1270-5 (2006) DOI:10.1136/gut.2005.087403 |