| H01331 | |
| H番号 | H01331 |
| 名称 | 齲蝕; 虫歯 |
| 概要 | Dental caries occurs due to demineralization of enamel and dentine (the hard tissues of the teeth) by organic acids formed by bacteria in dental plaque through the anaerobic metabolism of sugars derived from the diet. The 2 primary bacteria involved in caries formation are mutans streptococci and lactobacilli. When sugars or other fermentable carbohydrates are ingested, the resulting fall in dental plaque pH caused by organic acids increases the solubility of calcium hydroxyapatite in the dental hard tissues and demineralization occurs as calcium is lost from the tooth surface. The pH at which demineralization occurs is often referred to as the critical pH and is approximately 5.5. |
| カテゴリ | 細菌感染症 |
| ネットワーク | - |
| 病因遺伝子 | - |
| 病原体 | Streptococcus mutans [GN:smu smc smut smj] Cryptobacterium curtum [GN:ccu] Lactobacilli |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | フッ化ナトリウム [DR:D00943] フッ化ジアンミン銀 [DR:D01502] |
| コメント | - |
| リンク | ICD-11: DA08.0 ICD-10: K02 MedlinePlus: 001055 MeSH: D003731 |
| 文献 | PMID:14972061 著者 Moynihan P, Petersen PE タイトル Diet, nutrition and the prevention of dental diseases. 雑誌 Public Health Nutr 7:201-26 (2004) DOI:10.1079/PHN2003589 PMID:14522753 著者 Touger-Decker R, van Loveren C タイトル Sugars and dental caries. 雑誌 Am J Clin Nutr 78:881S-892S (2003) DOI:10.1093/ajcn/78.4.881S PMID:20331803 著者 Piwat S, Teanpaisan R, Thitasomakul S, Thearmontree A, Dahlen G タイトル Lactobacillus species and genotypes associated with dental caries in Thai preschool children. 雑誌 Mol Oral Microbiol 25:157-64 (2010) DOI:10.1111/j.2041-1014.2009.00556.x |