| H01333 | |
| H番号 | H01333 |
| 名称 | 非アルコール性脂肪肝疾患 |
| 概要 | It has been reported that those patients with non-alcoholic fatty liver disease (NAFLD) are probably more common in those individuals with metabolic syndrome, which includes obesity and type 2 diabetes mellitus. The spectrum of NAFLD ranges from simple steatosis to steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepatitis (NASH). Of those with NASH, approximately 20% will go on to develop cirrhosis and hepatocellular carcinoma. |
| カテゴリ | 消化器系疾患 疾患パスウェイ hsa04932 非アルコール性脂肪肝疾患 |
| ネットワーク | - |
| 病因遺伝子 | PNPLA3(polymorphism) [HSA:80339] [KO:K13534] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | - |
| コメント | - |
| リンク | ICD-11: DB92 ICD-10: K75.8 K76.0 |
| 文献 | PMID:20373368 著者 Valenti L, Al-Serri A, Daly AK, Galmozzi E, Rametta R, Dongiovanni P, Nobili V, Mozzi E, Roviaro G, Vanni E, Bugianesi E, Maggioni M, Fracanzani AL, Fargion S, Day CP タイトル Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease. 雑誌 Hepatology 51:1209-17 (2010) DOI:10.1002/hep.23622 PMID:20684021 著者 Rotman Y, Koh C, Zmuda JM, Kleiner DE, Liang TJ タイトル The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease. 雑誌 Hepatology 52:894-903 (2010) DOI:10.1002/hep.23759 PMID:20648472 著者 Speliotes EK, Butler JL, Palmer CD, Voight BF, Hirschhorn JN タイトル PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease. 雑誌 Hepatology 52:904-12 (2010) DOI:10.1002/hep.23768 |