| H01449 | |
| H番号 | H01449 |
| 名称 | 皮膚引っ掻き症 |
| 概要 | Excoriation Disorder, also known as Skin Picking Disorder, is characterized by the repetitive and compulsive scratching or picking of skin, which causes tissue damage. Patients spend a significant amount of time each day picking their skin, that causes psychosocial impairment. Triggers to pick vary greatly. For example, stress, anxiety, boredom, and feeling tired or angry have all been reported as triggers. Co-occurring psychiatric conditions are common in this disease. The most commonly reported comorbid conditions are trichotillomania, substance dependence, major depressive disorder, anxiety disorders, obsessive compulsive disorder (OCD), and body dysmorphic disorder (BDD). So far, there is no clear neurobiological explanation for the etiology of this disease. Recent research showed bilateral abnormalities in the anterior cingulate cortex and abnormalities on the left temporoparietal junction. Another study has shown deficits in motor inhibition, which appears to be correlated with frontal cortex abnormalities. Furthermore, severity of excoriation disorder may be associated with higher levels of impulsivity. Treatment for this disease has largely focused on cognitive behavioral therapy and pharmacology. Early psychosocial treatment studies provided evidence for skin picking reduction with habit reversal or acceptance-enhanced behavior therapy (AEBT). The data for selective serotonin reuptake inhibitors (SSRIs) efficacy in this disease are not convincing, although some studies suggested that fluoxetine is effective. Tricyclic antidepressants, neuroleptics, and the dopamine-blocking opioid antagonist have also been found to be effective for skin-picking. |
| カテゴリ | 精神及び行動の障害 |
| ネットワーク | - |
| 病因遺伝子 | - |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | - |
| コメント | In the fifth edition of Diagnostic and Statistical Manual of Mental Disorders (DSM-5), excoriation disorder has been subsumed into the obsessive-compulsive disorders and related disorders (OCDRD) category. |
| リンク | ICD-11: 6B25.1 ICD-10: F48.9 |
| 文献 | PMID:25591046 著者 Oliveira EC, Leppink EW, Derbyshire KL, Grant JE タイトル Excoriation disorder: impulsivity and its clinical associations. 雑誌 J Anxiety Disord 30:19-22 (2015) DOI:10.1016/j.janxdis.2014.12.010 PMID:23128921 著者 Grant JE, Odlaug BL, Chamberlain SR, Keuthen NJ, Lochner C, Stein DJ タイトル Skin picking disorder. 雑誌 Am J Psychiatry 169:1143-9 (2012) DOI:10.1176/appi.ajp.2012.12040508 PMID:20575652 著者 Odlaug BL, Grant JE タイトル Pathologic skin picking. 雑誌 Am J Drug Alcohol Abuse 36:296-303 (2010) DOI:10.3109/00952991003747543 PMID:18334614 (treatment) 著者 Flessner CA, Busch AM, Heideman PW, Woods DW タイトル Acceptance-enhanced behavior therapy (AEBT) for trichotillomania and chronic skin picking: exploring the effects of component sequencing. 雑誌 Behav Modif 32:579-94 (2008) DOI:10.1177/0145445507313800 PMID:20694122 (Drug) 著者 Jafferany M, Shireen F, Ibrahim A タイトル An open-label trial of topiramate in the treatment of skin picking in pervasive developmental disorder not otherwise specified. 雑誌 Prim Care Companion J Clin Psychiatry 12:PCC.09l00829 (2010) DOI:10.4088/PCC.09l00829yel |