| H01500 | |
| H番号 | H01500 |
| 名称 | ループス腎炎 |
| 概要 | Lupus nephritis is a severe organ manifestation of systemic lupus erythematosus (SLE) that can affect up to 70% of the SLE population. In childhood SLE, nephritis is present in up to 90% of the cases. This disease is one of the most serious complications of SLE, with a high morbidity and mortality. Clinical manifestations of active lupus nephritis include proteinuria, active urinary sediments, and progressive renal dysfunction. It is initiated by the deposition of immunoglobulins and formation of immune complexes in the glomerular and tubulo-interstitial compartments of the kidney. There is emerging evidence that the interaction between anti-dsDNA antibodies and kidney cells, notably mesangial cells, proximal renal tubular epithelial cells, and glomerular endothelial cells plays a significant role in disease pathogenesis. |
| カテゴリ | 免疫系疾患 |
| ネットワーク | - |
| 病因遺伝子 | - |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | タクロリムス水和物 [DR:D00107] ミコフェノール酸モフェチル [DR:D00752] ミゾリビン [DR:D01392] リツキシマブ [DR:D02994] |
| コメント | See also H00080 Systemic lupus erythematosus. Lupus nephritis is staged according to the classification revised by the International Society of Nephrology (ISN) and the Renal Pathology Society (RPS) in 2003. |
| リンク | ICD-11: 4A40.0Y ICD-10: M32.1 N08.5 MeSH: D008181 OMIM: 607965 607966 607967 |
| 文献 | PMID:14747370 著者 Weening JJ, D'Agati VD, Schwartz MM, Seshan SV, Alpers CE, Appel GB, Balow JE, Bruijn JA, Cook T, Ferrario F, Fogo AB, Ginzler EM, Hebert L, Hill G, Hill P, Jennette JC, Kong NC, Lesavre P, Lockshin M, Looi LM, Makino H, Moura LA, Nagata M タイトル The classification of glomerulonephritis in systemic lupus erythematosus revisited. 雑誌 J Am Soc Nephrol 15:241-50 (2004) DOI:10.1097/01.ASN.0000108969.21691.5D PMID:22761629 著者 Yung S, Chan TM タイトル Autoantibodies and resident renal cells in the pathogenesis of lupus nephritis: getting to know the unknown. 雑誌 Clin Dev Immunol 2012:139365 (2012) DOI:10.1155/2012/139365 PMID:12215904 著者 Quintero-Del-Rio AI, Kelly JA, Kilpatrick J, James JA, Harley JB タイトル The genetics of systemic lupus erythematosus stratified by renal disease: linkage at 10q22.3 (SLEN1), 2q34-35 (SLEN2), and 11p15.6 (SLEN3). 雑誌 Genes Immun 3 Suppl 1:S57-62 (2002) DOI:10.1038/sj.gene.6363901 PMID:22570338 著者 Wang S, Li X, Qu L, Wang R, Chen Y, Li Q, He X, Zhang X, Wang H, Wu J, Xu Y, Chen J タイトル Tacrolimus versus cyclophosphamide as treatment for diffuse proliferative or membranous lupus nephritis: a non-randomized prospective cohort study. 雑誌 Lupus 21:1025-35 (2012) DOI:10.1177/0961203312448105 PMID:19479701 著者 Pons-Estel GJ, Alarcon GS, McGwin G Jr, Danila MI, Zhang J, Bastian HM, Reveille JD, Vila LM タイトル Protective effect of hydroxychloroquine on renal damage in patients with lupus nephritis: LXV, data from a multiethnic US cohort. 雑誌 Arthritis Rheum 61:830-9 (2009) DOI:10.1002/art.24538 |