| H01580 | |
| H番号 | H01580 |
| 名称 | 壊血病; ビタミン C 欠乏症 |
| 概要 | Scurvy occurs because of reduced intake or absorption of vitamin C, which is characterized by bleeding gums, impaired wound healing, petechiae, perifollicular hemorrhage, anemia, arthralgia and joint effusions, fatigue, depression, and sudden death. It appears to result primarily from the decreased synthesis of collagen, a major protein in the body dependent on vitamin C for its biosynthesis. However, this role of vitamin C does not explain all of the manifestations associated with scurvy. At-risk groups include the poor (because of reduced access to groceries), food faddists, and individuals with purported allergies to multiple fruit and vegetable products. Other at-risk groups include persons with gastrointestinal disease (e.g. colitis), anatomical abnormalities, poor dentition, cancer patients on chemotherapy, patients on hemodialysis, and psychiatric disorders (e.g. depression, schizophrenia, or anorexia). Alcoholic persons represent one of the largest groups at risk for scurvy because they may have poorly balanced diets and because alcohol decreases the absorption of vitamin C. The diagnosis of scurvy is generally based on clinical features and dietary history, and there is rapid resolution of signs and symptoms after vitamin C supplementation. |
| カテゴリ | 先天性代謝異常症 |
| ネットワーク | - |
| 病因遺伝子 | - |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | アスコルビン酸 [DR:D00018] |
| コメント | - |
| リンク | ICD-11: 5B56 ICD-10: E54 MeSH: D012614 |
| 文献 | PMID:7946525 著者 Sauberlich HE タイトル Pharmacology of vitamin C. 雑誌 Annu Rev Nutr 14:371-91 (1994) DOI:10.1146/annurev.nu.14.070194.002103 PMID:16911372 著者 Olmedo JM, Yiannias JA, Windgassen EB, Gornet MK タイトル Scurvy: a disease almost forgotten. 雑誌 Int J Dermatol 45:909-13 (2006) DOI:10.1111/j.1365-4632.2006.02844.x |