| H01590 | |
| H番号 | H01590 |
| 名称 | 慢性好酸球性白血病 |
| 概要 | Chronic eosinophilic leukemia (CEL) is a chronic myeloproliferative disease of unknown etiology in which a clonal proliferation of eosinophilic precursors results in a persistently elevated number of eosinophils in blood, bone marrow or peripheral tissues. In most patients with CEL (about 60%), eosinophils display PDGFRA-fusion genes and related cytogenetic defects. The most commonly detected oncoprotein is FIP1L1/PDGFRA. FIP1L1-PDGFRA is a constitutively activated tyrosine kinase, which is suggested to induce the proliferation of EoL-1 (The eosinophilic leukemia cell line) cells by inducing c-Myc expression at the mRNA level via ERK and JNK signaling pathways. |
| カテゴリ | がん |
| ネットワーク | - |
| 病因遺伝子 | FIP1L1-PDGFRA (deletion) [HSA:5156] [KO:K04363] BCR-PDGFRA (translocation) [HSA:5156] [KO:K04363] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | イマチニブメシル酸塩 [DR:D01441] (FIP1L1-PDGFRα陽性) |
| コメント | - |
| リンク | ICD-11: 2A20.3 ICD-10: D47.5 MeSH: C580364 |
| 文献 | PMID:15070659 著者 Gotlib J, Cools J, Malone JM 3rd, Schrier SL, Gilliland DG, Coutre SE タイトル The FIP1L1-PDGFRalpha fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management. 雑誌 Blood 103:2879-91 (2004) DOI:10.1182/blood-2003-06-1824 PMID:23100928 著者 Kumar A, Sinha S, Tripathi AK タイトル Chronic eosinophilic leukemia: a case report and review of literature. 雑誌 Indian J Hematol Blood Transfus 23:112-5 (2007) DOI:10.1007/s12288-008-0010-2 PMID:23662039 著者 Yamada Y, Rothenberg ME, Cancelas JA タイトル Current concepts on the pathogenesis of the hypereosinophilic syndrome/chronic eosinophilic leukemia. 雑誌 Transl Oncogenomics 1:53-63 (2006) PMID:16781488 著者 Gotlib J, Cross NC, Gilliland DG タイトル Eosinophilic disorders: molecular pathogenesis, new classification, and modern therapy. 雑誌 Best Pract Res Clin Haematol 19:535-69 (2006) DOI:10.1016/j.beha.2005.07.013 PMID:19246139 著者 Valent P タイトル Pathogenesis, classification, and therapy of eosinophilia and eosinophil disorders. 雑誌 Blood Rev 23:157-65 (2009) DOI:10.1016/j.blre.2009.01.001 PMID:18086564 著者 Ishihara K, Kitamura H, Hiraizumi K, Kaneko M, Takahashi A, Zee O, Seyama T, Hong J, Ohuchi K, Hirasawa N タイトル Mechanisms for the proliferation of eosinophilic leukemia cells by FIP1L1-PDGFRalpha. 雑誌 Biochem Biophys Res Commun 366:1007-11 (2008) DOI:10.1016/j.bbrc.2007.12.063 PMID:16341034 著者 De Keersmaecker K, Cools J タイトル Chronic myeloproliferative disorders: a tyrosine kinase tale. 雑誌 Leukemia 20:200-5 (2006) DOI:10.1038/sj.leu.2404064 |