| H01611 | |
| H番号 | H01611 |
| 名称 | アルコール依存症 |
| 概要 | Alcohol dependence (AD) is a chronic but often disease that includes problems in controlling one's drinking, being preoccupied with alcohol, continuing to use alcohol even when it causes problems, having to drink more to get the same effect (physical dependence), or having withdrawal symptoms when one rapidly decreases or stops drinking. The contribution of genetic factors to the development of AD is high. The best classical candidate genes for AD are alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). Both genes are involved in enzymatic degradation of alcohol. Recent genome-wide association studies (GWAS) have reported that the most robust associations for AD have been with such enzyme genes, especially ALDH2 in East Asian populations and ADH1B in European American and African American populations. |
| カテゴリ | 精神及び行動の障害 疾患パスウェイ hsa05034 アルコール依存症 |
| ネットワーク | - |
| 病因遺伝子 | ALDH2 (polymorphism) [HSA:217] [KO:K00128] ADH1B (polymorphism) [HSA:125] [KO:K13951] ADH1C (polymorphism) [HSA:126] [KO:K13951] OPRM1 (polymorphism) [HSA:4988] [KO:K04215] DRD2 (polymorphism) [HSA:1813] [KO:K04145] HTR2A (polymorphism) [HSA:3356] [KO:K04157] GABRA2 (polymorphism) [HSA:2555] [KO:K05175] TAS2R16 (polymorphism) [HSA:50833] [KO:K08474] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | アカンプロサートカルシウム [DR:D02780] ナルメフェン塩酸塩水和物 [DR:D10812] シアナミド [DR:D00123] ジスルフィラム [DR:D00131] |
| コメント | - |
| リンク | ICD-11: 6C40.2 ICD-10: F10.2 F10.5 MeSH: D000437 OMIM: 103780 |
| 文献 | PMID:25985735 著者 Thompson A, Owens L, Pushpakom SP, Faizal M, Pirmohamed M タイトル Pharmacotherapy for alcohol dependence: A stratified approach. 雑誌 Pharmacol Ther 153:10-24 (2015) DOI:10.1016/j.pharmthera.2015.05.010 PMID:23810221 著者 Franck J, Jayaram-Lindstrom N タイトル Pharmacotherapy for alcohol dependence: status of current treatments. 雑誌 Curr Opin Neurobiol 23:692-9 (2013) DOI:10.1016/j.conb.2013.05.005 PMID:25359488 著者 Samochowiec J, Samochowiec A, Puls I, Bienkowski P, Schott BH タイトル Genetics of alcohol dependence: a review of clinical studies. 雑誌 Neuropsychobiology 70:77-94 (2014) DOI:10.1159/000364826 PMID:26110981 著者 Hart AB, Kranzler HR タイトル Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses. 雑誌 Alcohol Clin Exp Res 39:1312-27 (2015) DOI:10.1111/acer.12792 PMID:25278008 著者 Zuo L, Lu L, Tan Y, Pan X, Cai Y, Wang X, Hong J, Zhong C, Wang F, Zhang XY, Vanderlinden LA, Tabakoff B, Luo X タイトル Genome-wide association discoveries of alcohol dependence. 雑誌 Am J Addict 23:526-39 (2014) DOI:10.1111/j.1521-0391.2014.12147.x PMID:24456374 著者 Muller CA, Geisel O, Banas R, Heinz A タイトル Current pharmacological treatment approaches for alcohol dependence. 雑誌 Expert Opin Pharmacother 15:471-81 (2014) DOI:10.1517/14656566.2014.876008 PMID:23170934 著者 Rietschel M, Treutlein J タイトル The genetics of alcohol dependence. 雑誌 Ann N Y Acad Sci 1282:39-70 (2013) DOI:10.1111/j.1749-6632.2012.06794.x PMID:25408904 著者 Nieratschker V, Batra A, Fallgatter AJ タイトル Genetics and epigenetics of alcohol dependence. 雑誌 J Mol Psychiatry 1:11 (2013) DOI:10.1186/2049-9256-1-11 PMID:16534506 著者 Prescott CA, Sullivan PF, Kuo PH, Webb BT, Vittum J, Patterson DG, Thiselton DL, Myers JM, Devitt M, Halberstadt LJ, Robinson VP, Neale MC, van den Oord EJ, Walsh D, Riley BP, Kendler KS タイトル Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4. 雑誌 Mol Psychiatry 11:603-11 (2006) DOI:10.1038/sj.mp.4001811 |