| H01625 | |
| H番号 | H01625 |
| 名称 | バージャー病; ビュルガー病; 閉塞性血栓血管炎 |
| 概要 | Buerger disease, also known as thromboangiitis obliterans, is a nonatherosclerotic, inflammatory disease that most commonly affects the small and medium-sized arteries and veins in the upper and lower extremities. Cigarette smoking has been implicated as the main etiology of the disease. Although Buerger's disease has a worldwide distribution, it is more prevalent in the Middle East and Far East and classically develops in male smokers younger than 45 years. There may be a predisposition to development of Buerger's disease, although no gene has been identified to date. The most common symptom is pain at rest and claudication in the affected hands or feet. Other symptoms include cold insensitivity, diminished peripheral pulses, cyanosis, skin atrophy, and reduced hair growth. As the disease progresses, patients will develop ischemic ulcerations and eventually gangrene. Abstinence from smoking is the definitive treatment to prevent disease progression. Medical line of treatment with vasodilators, pentoxyfylline, and cilostazol may help improve pain-free walking distance but cannot prevent disease progression. Surgical treatment in form of revascularization and sympathectomy increases peripheral blood flow and decreases the rate of amputations. Newer therapy with prostaglandins, bosentan, and stem cell therapy has shown promising results. |
| カテゴリ | 免疫系疾患 |
| ネットワーク | - |
| 病因遺伝子 | - |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | イソクスプリン塩酸塩 [DR:D01748] ヘプロニカート [DR:D01882] ニセリトロール [DR:D01754] アルガトロバン水和物 [DR:D00181] アルプロスタジル [DR:D00180] アルプロスタジル アルファデクス [DR:D02705] リマプロストアルファデクス [DR:D02860] カリジノゲナーゼ [DR:D03330] バトロキソビン [DR:D03352] ベペルミノゲンペルプラスミド [DR:D09839] |
| コメント | - |
| リンク | ICD-11: 4A44.8 ICD-10: I73.1 MeSH: D013919 OMIM: 211480 |
| 文献 | PMID:27144003 著者 Rivera-Chavarria IJ, Brenes-Gutierrez JD タイトル Thromboangiitis obliterans (Buerger's disease). 雑誌 Ann Med Surg (Lond) 7:79-82 (2016) DOI:10.1016/j.amsu.2016.03.028 PMID:25987945 著者 Sinclair NR, Laub DR タイトル Thromboangiitis Obliterans (Buerger's Disease). 雑誌 Eplasty 15:ic22 (2015) PMID:24102033 著者 Vijayakumar A, Tiwari R, Kumar Prabhuswamy V タイトル Thromboangiitis Obliterans (Buerger's Disease)-Current Practices. 雑誌 Int J Inflam 2013:156905 (2013) DOI:10.1155/2013/156905 |