| H01665 | |
| H番号 | H01665 |
| 名称 | 原発性腹膜癌 |
| 概要 | Female primary peritoneal carcinoma (PPC) has the characteristic of diffuse involvement of the peritoneum by papillary carcinoma in the absence of an obvious primary site and grossly normal ovaries, or minimal involvement. It is histologically indistinguishable from primary epithelial ovarian carcinoma (EOC) and is diagnosed in the absence of another identifiable primary. Most reported PPC cases are primary peritoneal serous papillary carcinoma (PPSPC), while peritoneal mixed epithelial carcinoma (MEC) and malignant mixed Mullerian tumor (MMMT) are rarely reported. Germline BRCA1 mutations in 26% of PPSPC patients was detected. BRCA1 mutation carriers had a higher overall incidence of p53 mutations than wildtype BRCA1 case subjects. It is suggested that p53 has a unique role in the development and progression of BRCA1-related PPSPC. |
| カテゴリ | がん |
| ネットワーク | - |
| 病因遺伝子 | BRCA1 (mutation) [HSA:672] [KO:K10605] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | - |
| コメント | - |
| リンク | ICD-11: 2C51 ICD-10: C48.1 MeSH: D010534 |
| 文献 | PMID:11014956 著者 Cormio G, Di Vagno G, Di Gesu G, Mastroianni M, Melilli GA, Vimercati A, Putignano G, Loverro G, Selvaggi L タイトル Primary peritoneal carcinoma: a report of twelve cases and a review of the literature. 雑誌 Gynecol Obstet Invest 50:203-6 (2000) DOI:10.1159/000010311 PMID:19897383 著者 Pentheroudakis G, Pavlidis N タイトル Serous papillary peritoneal carcinoma: unknown primary tumour, ovarian cancer counterpart or a distinct entity? A systematic review. 雑誌 Crit Rev Oncol Hematol 75:27-42 (2010) DOI:10.1016/j.critrevonc.2009.10.003 PMID:10728699 著者 Schorge JO, Muto MG, Lee SJ, Huang LW, Welch WR, Bell DA, Keung EZ, Berkowitz RS, Mok SC タイトル BRCA1-related papillary serous carcinoma of the peritoneum has a unique molecular pathogenesis. 雑誌 Cancer Res 60:1361-4 (2000) PMID:21352070 著者 Slomovitz BM, Worley MJ, Markman M, Coleman RL タイトル Emerging therapeutics for primary peritoneal cancer. 雑誌 Expert Opin Emerg Drugs 16:71-84 (2011) DOI:10.1517/14728214.2011.526600 PMID:18543395 著者 Zhang C, Li XP, Cui H, Shen DH, Wei LH タイトル Advanced primary peritoneal carcinoma: clinicopathological and prognostic factor analyses. 雑誌 J Zhejiang Univ Sci B 9:435-40 (2008) DOI:10.1631/jzus.B0820051 PMID:25315029 著者 Keating GM タイトル Bevacizumab: a review of its use in advanced cancer. 雑誌 Drugs 74:1891-925 (2014) DOI:10.1007/s40265-014-0302-9 |