| H01670 | |
| H番号 | H01670 |
| 名称 | 社会不安障害 |
| 概要 | Social anxiety disorder (SAD) is the most common anxiety disorder. SAD is generally considered a chronic disorder and has its onset during early adolescence. It is a risk factor for subsequent depressive illness and substance abuse. Patients with SAD have an extreme fear of being negatively evaluated in social situations and, as a result, avoid social events or endure them with excessive fear or anxiety. Although the etiology of SAD is not yet fully established, twin and family studies suggest that SAD is heritable. Functional neuroimaging studies point to increased activity in amygdala and insula in patients with social anxiety disorder. In addition, there is evidence from various studies, that the serotonin, and dopamine neurotransmitter systems mediate the symptoms of SAD. A range of effective cognitive behavioural and pharmacological treatments now exists. However, they don't work for the 30-40% of patients. |
| カテゴリ | 精神及び行動の障害 |
| ネットワーク | - |
| 病因遺伝子 | - |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | パロキセチン塩酸塩水和物 [DR:D02260] フルボキサミンマレイン酸塩 [DR:D00824] エスシタロプラムシュウ酸塩 [DR:D02567] |
| コメント | - |
| リンク | ICD-11: 6B04 ICD-10: F40.1 F93.2 MeSH: D010698 |
| 文献 | PMID:18374843 著者 Stein MB, Stein DJ タイトル Social anxiety disorder. 雑誌 Lancet 371:1115-25 (2008) DOI:10.1016/S0140-6736(08)60488-2 PMID:27593443 著者 Bas-Hoogendam JM, Blackford JU, Bruhl AB, Blair KS, van der Wee NJA, Westenberg PM タイトル Neurobiological candidate endophenotypes of social anxiety disorder. 雑誌 Neurosci Biobehav Rev 71:362-378 (2016) DOI:10.1016/j.neubiorev.2016.08.040 PMID:16899354 著者 Lochner C, Hemmings S, Seedat S, Kinnear C, Schoeman R, Annerbrink K, Olsson M, Eriksson E, Moolman-Smook J, Allgulander C, Stein DJ タイトル Genetics and personality traits in patients with social anxiety disorder: a case-control study in South Africa. 雑誌 Eur Neuropsychopharmacol 17:321-7 (2007) DOI:10.1016/j.euroneuro.2006.06.010 |