| H01674 | |
| H番号 | H01674 |
| 名称 | 強直性脊椎炎; ベヒテレフ病 |
| 概要 | Ankylosing spondylitis (AS), formerly also known as Bechterew's disease, is a rheumatic disease of the axial skeleton that mainly affects the spine and the sacroiliac joint in the pelvis. AS is one of a group of inflammatory diseases, called spondyloarthritides, which share features. This disease is characterized by erosion, sclerosis, and ossification, which may result in complete fusion and rigidity of the spine. Regarding extra-articular manifestations, the most frequent is anterior uveitis. The major functional losses occur during the first 10 years of disease. It usually begins in the second or third decade of life, preferentially in HLA-B27-positive Caucasian males. Its etiology and pathogenesis are not completely understood, but the most prevalent hypothesis involves immune mediation as its major mechanism, including several cytokines. To date, more than 40 genetic variants have been identified that influence the risk of developing AS, including HLA alleles such as HLA-B27. |
| カテゴリ | 筋骨格疾患 |
| ネットワーク | - |
| 病因遺伝子 | HLA-B [HSA:3106] [KO:K06751] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | アスピリン [DR:D00109] ナプロキセン [DR:D00118] デキサメタゾン [DR:D00292] デキサメタゾンリン酸エステルナトリウム [DR:D00975] ベタメタゾンリン酸エステルナトリウム [DR:D00972] トリアムシノロンアセトニド [DR:D00983] インフリキシマブ [DR:D02598] ヒドロコルチゾンコハク酸エステルナトリウム [DR:D00978] トリアムシノロン [DR:D00385] ベタメタゾン [DR:D00244] プレドニゾロン [DR:D00472] プレドニゾロンコハク酸エステルナトリウム [DR:D01239] メチルプレドニゾロン酢酸エステル [DR:D00979] ウパダシチニブ水和物 [DR:D11048] アダリムマブ [DR:D02597] セクキヌマブ [DR:D09967] ブロダルマブ [DR:D10061] イキセキズマブ [DR:D10071] |
| コメント | See also H00630 Rheumatoid arthritis and H01656 Psoriasis. |
| リンク | ICD-11: FA92 ICD-10: M45 MeSH: D013167 OMIM: 106300 |
| 文献 | PMID:23090374 著者 Gouveia EB, Elmann D, Morales MS タイトル Ankylosing spondylitis and uveitis: overview. 雑誌 Rev Bras Reumatol 52:742-56 (2012) DOI:10.1590/S0482-50042012000500009 PMID:27445458 著者 Koenders MI, van den Berg WB タイトル Secukinumab for rheumatology: development and its potential place in therapy. 雑誌 Drug Des Devel Ther 10:2069-80 (2016) DOI:10.2147/DDDT.S105263 PMID:26439405 著者 Brown MA, Kenna T, Wordsworth BP タイトル Genetics of ankylosing spondylitis--insights into pathogenesis. 雑誌 Nat Rev Rheumatol 12:81-91 (2016) DOI:10.1038/nrrheum.2015.133 |