| H01676 | |
| H番号 | H01676 |
| 名称 | 正常圧水頭症 |
| 概要 | Normal pressure hydrocephalus (NPH) is a progressive brain disease characterized by gait impairment, urinary incontinence, and dementia, and by ventricular enlargement in the absence of elevated intracranial pressure. NPH can be secondary to disease processes that cause inflammation of the arachnoid, such as subarachnoid hemorrhage, traumatic brain injury, or meningitis. As many as half of patients with NPH have no identifiable risk factor, and it is called idiopathic normal pressure hydrocephalus (INPH). Although INPH is usually considered an acquired form of hydrocephalus because the onset of symptoms is not until late in life, it has been reported that a subset of patients with INPH may actually have congenital hydrocephalus. Symptoms can be alleviated with a cerebrospinal fluid (CSF) shunt. |
| カテゴリ | 神経系疾患 |
| ネットワーク | - |
| 病因遺伝子 | - |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | - |
| コメント | - |
| リンク | ICD-11: 8D64.04 ICD-10: G91.2 MeSH: D006850 OMIM: 236690 611808 |
| 文献 | PMID:25061869 著者 Golz L, Ruppert FH, Meier U, Lemcke J タイトル Outcome of modern shunt therapy in patients with idiopathic normal pressure hydrocephalus 6 years postoperatively. 雑誌 J Neurosurg 121:771-5 (2014) DOI:10.3171/2014.6.JNS131211 PMID:17202229 著者 Wilson RK, Williams MA タイトル Evidence that congenital hydrocephalus is a precursor to idiopathic normal pressure hydrocephalus in only a subset of patients. 雑誌 J Neurol Neurosurg Psychiatry 78:508-11 (2007) DOI:10.1136/jnnp.2006.108761 PMID:16239882 (treatment) 著者 McGirt MJ, Woodworth G, Coon AL, Thomas G, Williams MA, Rigamonti D タイトル Diagnosis, treatment, and analysis of long-term outcomes in idiopathic normal-pressure hydrocephalus. 雑誌 Neurosurgery 57:699-705; discussion 699-705 (2005) DOI:10.1227/01.NEU.0000175724.00147.10 PMID:18203159 著者 Zhang J, Williams MA, Rigamonti D タイトル Heritable essential tremor-idiopathic normal pressure hydrocephalus (ETINPH). 雑誌 Am J Med Genet A 146A:433-9 (2008) DOI:10.1002/ajmg.a.31958 |