| H01680 | |
| H番号 | H01680 |
| 名称 | 慢性膵炎 |
| 概要 | Chronic pancreatitis is a progressive inflammatory disease of the pancreas that will finally result in both exocrine and endocrine insufficiency. Chronic pancreatitis develops gradually and worsens over time, resulting in permanent organ damage. It is usually caused by recurrent episodes of pancreatic necro-inflammation, leading to pancreatic atrophy and dysfunction. It manifests clinically as maldigestion, weight loss, abdominal pain and eventually diabetes. Six major etiologies for chronic pancreatitis have been identified, namely toxic-metabolic (including alcohol), idiopathic, genetic, autoimmune, recurrent and severe acute pancreatitis, and obstruction. Oral protease inhibitors are currently used as a medical treatment for chronic pancreatitis. |
| カテゴリ | 消化器系疾患 |
| ネットワーク | - |
| 病因遺伝子 | - |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | トレピブトン [DR:D01365] カモスタットメシル酸塩 [DR:D01766] ナファモスタットメシル酸塩 [DR:D01670] ガベキサートメシル酸塩 [DR:D01672] |
| コメント | See also H00933 Hereditary pancreatitis. |
| リンク | ICD-11: DC32 ICD-10: K86.1 MeSH: D050500 OMIM: 167800 |
| 文献 | PMID:20567557 著者 Banks PA, Conwell DL, Toskes PP タイトル The management of acute and chronic pancreatitis. 雑誌 Gastroenterol Hepatol (N Y) 6:1-16 (2010) PMID:18442214 著者 Frossard JL, Dumonceau JM, Pastor C, Spahr L, Hadengue A タイトル Concomitant autoimmune and genetic pancreatitis leads to severe inflammatory conditions. 雑誌 World J Gastroenterol 14:2596-8 (2008) DOI:10.3748/wjg.14.2596 PMID:25228979 著者 Hirano K, Saito T, Mizuno S, Tada M, Sasahira N, Isayama H, Matsukawa M, Umefune G, Akiyama D, Saito K, Kawahata S, Takahara N, Uchino R, Hamada T, Miyabayashi K, Mohri D, Sasaki T, Kogure H, Yamamoto N, Nakai Y, Koike K タイトル Total cholesterol level for assessing pancreatic insufficiency due to chronic pancreatitis. 雑誌 Gut Liver 8:563-8 (2014) DOI:10.5009/gnl13366 PMID:17625311 著者 Motoo Y タイトル Antiproteases in the treatment of chronic pancreatitis. 雑誌 JOP 8:533-7 (2007) PMID:17625312 著者 Kitagawa M, Hayakawa T タイトル Antiproteases and the pancreas: basic and clinical update. Conclusion remarks. 雑誌 JOP 8:538-44 (2007) |