| H01690 | |
| H番号 | H01690 |
| 名称 | 硬化性萎縮性苔癬 |
| 概要 | Lichen sclerosus et atrophicus (LSA) is a chronic inflammatory dermatitis affecting primarily vulvar, perianal and perineal skin. Extragenital lichen sclerosus is most common on the neck, shoulders, and upper portion of the trunk. It is generally asymptomatic or is occasionally pruritic and presents as flat, white, polygonal papules and atrophic white plaques. It is primarily seen in postmenopausal women, but also men and children can be affected. The aetiology is not clearly established, although there is a strong association with autoimmune diseases. Morphea may coexist with LSA. Standard treatment includes topical corticosteroid and calcineurin inhibitors, such as tacrolimus. The association between LSA and squamous cell carcinoma (SCC) is confirmed and has been described chiefly in females. The risk of SCC of the vulva has been estimated to about 5% in women with LSA. |
| カテゴリ | 免疫系疾患; 皮膚疾患 |
| ネットワーク | - |
| 病因遺伝子 | - |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | - |
| コメント | See also H01493 Localized Scleroderma. |
| リンク | ICD-11: EB60 ICD-10: L90.0 MeSH: D008011 OMIM: 151590 |
| 文献 | PMID:26500867 著者 Diwan NG, Nair PA タイトル Extragenital lichen sclerosus et atrophicus along the lines of Blaschko. 雑誌 Indian Dermatol Online J 6:342-4 (2015) DOI:10.4103/2229-5178.164486 PMID:24470666 著者 Kar BR, Dash K タイトル Co-existence of Lichen Sclerosus et Atrophicus and Morphoea Along Lines of Blaschko. 雑誌 Indian J Dermatol 59:77-9 (2014) DOI:10.4103/0019-5154.123507 PMID:24549239 著者 Kantere D, Lowhagen GB, Alvengren G, Maneskold A, Gillstedt M, Tunback P タイトル The clinical spectrum of lichen sclerosus in male patients - a retrospective study. 雑誌 Acta Derm Venereol 94:542-6 (2014) DOI:10.2340/00015555-1797 |