| H01701 | |
| H番号 | H01701 |
| 名称 | 下垂体性 TSH 分泌亢進症; TSH不適切分泌症候群 (SITSH) |
| 概要 | Pituitary TSH hypersecretion is disease of the anterior portion of the pituitary resulting in hypersecretion of thyroid stimulating hormone (TSH). It includes two forms of central hyperthyroidism, i.e. TSH-secreting pituitary adenoma (TSHoma) and resistance to thyroid hormone action (RTH). The incidence of hyperthyroidism due to a TSHoma is extremely low, 1-2% of all cases of hyperthyroidism. Most of the tumors are macroadenomas usually presenting with symptoms such as headache and/or visual field impairment while the symptoms of hyperthyroidism seem to be milder compared with those caused by primary hyperthyroidism. First-line treatment of TSHoma is pituitary adenomectomy followed by irradiation in the case of surgical failure. However, medical treatment with somatostatin analogs, such as octreotide and lanreotide, are effective in reducing TSH secretion. |
| カテゴリ | 内分泌代謝疾患 |
| ネットワーク | - |
| 病因遺伝子 | - |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | - |
| コメント | See also H00249 Thyroid hormone resistance syndrome, H01102 Pituitary adenomas, and H01645 Hyperthyroidism. |
| リンク | ICD-11: 5A60.Y ICD-10: E22.9 MeSH: D006964 |
| 文献 | PMID:25905212 著者 Beck-Peccoz P, Persani L, Lania A タイトル Thyrotropin-Secreting Pituitary Adenomas 雑誌 Endotext (2000) PMID:23402621 著者 Tong A, Xia W, Qi F, Jin Z, Yang D, Zhang Z, Li F, Xing X, Lian X タイトル Hyperthyroidism caused by an ectopic thyrotropin-secreting tumor of the nasopharynx: a case report and review of the literature. 雑誌 Thyroid 23:1172-7 (2013) DOI:10.1089/thy.2012.0574 PMID:26765410 著者 Mousiolis AC, Rapti E, Grammatiki M, Yavropoulou M, Efstathiou M, Foroglou N, Daniilidis M, Kotsa K タイトル Somatostatin Analogue Treatment of a TSH-Secreting Adenoma Presenting With Accelerated Bone Metabolism and a Pericardial Effusion: A Case Report. 雑誌 Medicine (Baltimore) 95:e2358 (2016) DOI:10.1097/MD.0000000000002358 PMID:24783044 著者 Beck-Peccoz P, Lania A, Beckers A, Chatterjee K, Wemeau JL タイトル 2013 European thyroid association guidelines for the diagnosis and treatment of thyrotropin-secreting pituitary tumors. 雑誌 Eur Thyroid J 2:76-82 (2013) DOI:10.1159/000351007 |