| H01739 | |
| H番号 | H01739 |
| 名称 | 多嚢胞性卵巣症候群 |
| 概要 | Polycystic ovary syndrome (PCOS) is a common heterogeneous endocrine disorder characterized by elevated androgen levels, menstrual irregularities, and/or small cysts on one or both ovaries. Clinical manifestations include oligomenorrhea or amenorrhea, hirsutism, and frequently infertility. Clinical signs of PCOS include elevated luteinizing hormone (LH) and gonadotropin-releasing hormone (GnRH) levels, whereas follicle-stimulating hormone (FSH) levels are muted or unchanged. As a result of the increase in GnRH, stimulation of the ovarian theca cells, in turn, produces more androgens. Risk factors for PCOS in adults include insulin resistance (IR), type 2 diabetes, obesity, and cardiovascular disease. PCOS can be described as an oligogenic disorder in which the interactions of a number of genetic and environmental factors determine the heterogeneous, clinical, and biochemical phenotype. Management of clinical manifestations of PCOS includes oral contraceptives for menstrual irregularities and hirsutism. Treatment options for infertility include clomiphene, laparoscopic ovarian drilling, gonadotropins, and assisted reproductive technology. |
| カテゴリ | 内分泌代謝疾患 |
| ネットワーク | - |
| 病因遺伝子 | - |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | 精製下垂体性性腺刺激ホルモン [DR:D06459] ホリトロピンアルファ [DR:D04429] レトロゾール [DR:D00964] メトホルミン塩酸塩 [DR:D00944] |
| コメント | - |
| リンク | ICD-11: 5A80.1 ICD-10: E28.2 MeSH: D011085 |
| 文献 | PMID:24379699 著者 Sirmans SM, Pate KA タイトル Epidemiology, diagnosis, and management of polycystic ovary syndrome. 雑誌 Clin Epidemiol 6:1-13 (2013) DOI:10.2147/CLEP.S37559 PMID:23946629 著者 Ndefo UA, Eaton A, Green MR タイトル Polycystic ovary syndrome: a review of treatment options with a focus on pharmacological approaches. 雑誌 P T 38:336-55 (2013) PMID:24389146 著者 Barthelmess EK, Naz RK タイトル Polycystic ovary syndrome: current status and future perspective. 雑誌 Front Biosci (Elite Ed) 6:104-19 (2014) DOI:10.2741/e695 |