| H01841 | |
| H番号 | H01841 |
| 名称 | 痙攣重積型 (二相性) 急性脳症 |
| 概要 | Acute encephalopathy with biphasic seizures and reduced diffusion (AESD) is a syndrome of encephalopathy characterized by biphasic seizures. The etiology of AESD has been attributed to viral infection like influenza A and human herpes virus 6. AESD is the most common subtype of infectious pediatric encephalopathy in Japan, and is often observed in children with neurological problems, such as intellectual disability and motor delay. AESD is clinically characterized by a prolonged febrile seizure on day 1, followed by late seizures associated with deterioration of the consciousness level on days 4 to 6, and is radiologically characterized by delayed reduced diffusion in the frontal or frontoparietal subcortical white matter, the so-called bright tree appearance, on days 3 to 9. The exact pathogenesis of AESD is uncertain, however, excitotoxic injury with delayed (or apoptotic) neuronal death is hypothesized to be a possible mechanism. |
| カテゴリ | 神経系疾患 |
| ネットワーク | - |
| 病因遺伝子 | - |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | - |
| コメント | - |
| リンク | ICD-11: 8E47 ICD-10: G93.4 |
| 文献 | PMID:27288783 著者 Fujita Y, Takanashi J, Takei H, Ota S, Fujii K, Sakuma H, Hayashi M タイトル Activated microglia in acute encephalopathy with biphasic seizures and late reduced diffusion. 雑誌 J Neurol Sci 366:91-3 (2016) DOI:10.1016/j.jns.2016.04.050 PMID:23772250 著者 Yadav SS, Lawande MA, Kulkarni SD, Patkar DA タイトル Acute encephalopathy with biphasic seizures and late reduced diffusion. 雑誌 J Pediatr Neurosci 8:64-6 (2013) DOI:10.4103/1817-1745.111429 |