| H01863 | |
| H番号 | H01863 |
| 名称 | アトピー性脊髄炎 |
| 概要 | Atopic myelitis, also described as idiopathic eosinophilic myelitis, is a rare disease that consists of localised and persistent inflammation of the spinal cord. It has been reported predominantly in Japan. This disease has specific features of elevated serum IgE level, active reaction to mite or cedar pollen specific antigen and stepwise progression of mostly the sensory symptoms. Atopic myelitis is often with coexistent atopic diseases, such as atopic dermatitis, bronchial asthma, allergic rhinitis and food allergies. Although the pathogenesis is still poorly understood, it has been reported that CCL11 and IL-9 were significantly increased in patients with atopic myelitis. Upregulation of CCL11 and IL-9 explain quite well the eosinophilic inflammation of the spinal cord. It has been suggested that immunotherapy, such as corticosteroids, intravenous immunoglobulin (IVIG), and plasma exchanges (PE), are effective in atopic myelitis, and that PE is the most beneficial immunotherapy. |
| カテゴリ | 免疫系疾患 |
| ネットワーク | - |
| 病因遺伝子 | - |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | - |
| コメント | See also H00079 Asthma and H01358 Atopic dermatitis. |
| リンク | ICD-11: 8B41 ICD-10: G04.8 |
| 文献 | PMID:18809833 著者 Tanaka M, Matsushita T, Tateishi T, Ochi H, Kawano Y, Mei FJ, Minohara M, Murai H, Kira JI タイトル Distinct CSF cytokine/chemokine profiles in atopic myelitis and other causes of myelitis. 雑誌 Neurology 71:974-81 (2008) DOI:10.1212/01.wnl.0000326589.57128.c3 PMID:16782129 著者 Gregoire SM, Mormont E, Laloux P, Godfraind C, Gilliard C タイトル Atopic myelitis: a clinical, biological, radiological and histopathological diagnosis. 雑誌 J Neurol Sci 247:231-5 (2006) DOI:10.1016/j.jns.2006.05.045 PMID:15546590 著者 Murai H, Arahata H, Osoegawa M, Ochi H, Minohara M, Taniwaki T, Tobimatsu S, Mihara F, Tsuruta Y, Inaba S, Kira J タイトル Effect of immunotherapy in myelitis with atopic diathesis. 雑誌 J Neurol Sci 227:39-47 (2004) DOI:10.1016/j.jns.2004.08.001 |