| H01874 | |
| H番号 | H01874 |
| 名称 | クロンカイト・カナダ症候群 |
| 概要 | Cronkhite-Canada syndrome (CCS) is a rare noninherited condition characterized by gastrointestinal hamartomatous polyposis, alopecia, onychodystrophy, hyperpigmentation, and diarrhea. CCS is reported worldwide, with 75% of cases in Japan. The average age of onset is 60 years and the male to female ratio is 3:2. At present, the pathogenesis of CCS is unknown, but the factors that include immune abnormalities, infection, and allergies, may be relevant. There are no evidence-based therapies. Numerous treatments have been attempted in CCS patients, with varying degrees of success. These treatments include glucocorticoids, nutritional support, antibiotics, and polypectomy. |
| カテゴリ | 消化器系疾患 |
| ネットワーク | - |
| 病因遺伝子 | - |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | - |
| コメント | - |
| リンク | ICD-11: LD27.01 ICD-10: D13.9 MeSH: D044483 OMIM: 175500 |
| 文献 | PMID:22675285 著者 Sweetser S, Boardman LA タイトル Cronkhite-Canada syndrome: an acquired condition of gastrointestinal polyposis and dermatologic abnormalities. 雑誌 Gastroenterol Hepatol (N Y) 8:201-3 (2012) PMID:24966624 著者 Wen XH, Wang L, Wang YX, Qian JM タイトル Cronkhite-Canada syndrome: report of six cases and review of literature. 雑誌 World J Gastroenterol 20:7518-22 (2014) DOI:10.3748/wjg.v20.i23.7518 |