| H01895 | |
| H番号 | H01895 |
| 名称 | 注意欠陥多動障害 (ADHD) |
| 概要 | Attention-deficit hyperactivity disorder (ADHD) is a common psychiatric disorder first diagnosed in childhood and frequently persistent throughout adult life. The disorder is classically characterized by symptoms of inattention, impulsivity, and hyperactivity. Many children with ADHD go on to have problems related to education, social functioning, and/or other mental illness as adolescents and young adults. Although heritability estimates are consistently high, ADHD is a genetically complex disorder characterized by multifactorial inheritance involving numerous genes of moderate effect. Reports implicate variants of genes important for the synthesis, uptake, transport and receptor binding of dopamine in the etiology of ADHD. And interaction between the dopamine and serotonin systems has been implicated in both the pathophysiology of ADHD and the mechanism of action of widely used stimulant compounds. |
| カテゴリ | 精神及び行動の障害 |
| ネットワーク | - |
| 病因遺伝子 | (ADHD) DRD5 [HSA:1816] [KO:K05840] (ADHD) DRD4 [HSA:1815] [KO:K04147] (ADHD7) TPH2 [HSA:121278] [KO:K00502] (ADHD8) CDH2 [HSA:1000] [KO:K06736] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | グアンファシン塩酸塩 [DR:D00606] メチルフェニデート塩酸塩 [DR:D01296] アトモキセチン塩酸塩 [DR:D02574] リスデキサンフェタミンメシル酸塩 [DR:D04747] |
| コメント | - |
| リンク | ICD-11: 6A05 ICD-10: F90.0 MeSH: D001289 OMIM: 143465 613003 619957 |
| 文献 | PMID:24214656 著者 Matthews M, Nigg JT, Fair DA タイトル Attention deficit hyperactivity disorder. 雑誌 Curr Top Behav Neurosci 16:235-66 (2014) DOI:10.1007/7854_2013_249 PMID:24627974 著者 Roskell NS, Setyawan J, Zimovetz EA, Hodgkins P タイトル Systematic evidence synthesis of treatments for ADHD in children and adolescents: indirect treatment comparisons of lisdexamfetamine with methylphenidate and atomoxetine. 雑誌 Curr Med Res Opin 30:1673-85 (2014) DOI:10.1185/03007995.2014.904772 PMID:26170637 著者 Bello NT タイトル Clinical utility of guanfacine extended release in the treatment of ADHD in children and adolescents. 雑誌 Patient Prefer Adherence 9:877-85 (2015) DOI:10.2147/PPA.S73167 PMID:14699430 (ADHD) 著者 Kustanovich V, Ishii J, Crawford L, Yang M, McGough JJ, McCracken JT, Smalley SL, Nelson SF タイトル Transmission disequilibrium testing of dopamine-related candidate gene polymorphisms in ADHD: confirmation of association of ADHD with DRD4 and DRD5. 雑誌 Mol Psychiatry 9:711-7 (2004) DOI:10.1038/sj.mp.4001466 PMID:16116490 (ADHD7) 著者 Walitza S, Renner TJ, Dempfle A, Konrad K, Wewetzer Ch, Halbach A, Herpertz-Dahlmann B, Remschmidt H, Smidt J, Linder M, Flierl L, Knolker U, Friedel S, Schafer H, Gross C, Hebebrand J, Warnke A, Lesch KP タイトル Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder. 雑誌 Mol Psychiatry 10:1126-32 (2005) DOI:10.1038/sj.mp.4001734 PMID:34702855 (ADHD8) 著者 Halperin D, Stavsky A, Kadir R, Drabkin M, Wormser O, Yogev Y, Dolgin V, Proskorovski-Ohayon R, Perez Y, Nudelman H, Stoler O, Rotblat B, Lifschytz T, Lotan A, Meiri G, Gitler D, Birk OS タイトル CDH2 mutation affecting N-cadherin function causes attention-deficit hyperactivity disorder in humans and mice. 雑誌 Nat Commun 12:6187 (2021) DOI:10.1038/s41467-021-26426-1 |