| H01899 | |
| H番号 | H01899 |
| 名称 | 読字障害 |
| 概要 | Dyslexia is defined by severe difficulties in reading acquisition, often accompanied by spelling difficulties and affects a large number of people (5-10%). It is caused by multiple genetic and environmental risk factors as well as their interplay. Several candidate genes have been identified in the past decade. However, effects of individual genetic variations on dyslexia-associated deficits are only moderate. At the brain level, dyslexia is associated with aberrant structure and function, particularly in left hemisphere reading-language networks. |
| カテゴリ | 精神及び行動の障害 |
| ネットワーク | - |
| 病因遺伝子 | (DYX1) DNAAF4 [HSA:161582] [KO:K19758] (DYX2) AAVR [HSA:9856] [KO:K24403] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | - |
| コメント | - |
| リンク | ICD-11: MB4B.0 ICD-10: R48.0 MeSH: D004410 OMIM: 127700 600202 |
| 文献 | PMID:25594880 著者 Peterson RL, Pennington BF タイトル Developmental dyslexia. 雑誌 Annu Rev Clin Psychol 11:283-307 (2015) DOI:10.1146/annurev-clinpsy-032814-112842 PMID:20862559 著者 Svensson I, Nilsson S, Wahlstrom J, Jernas M, Carlsson LM, Hjelmquist E タイトル Familial dyslexia in a large Swedish family: a whole genome linkage scan. 雑誌 Behav Genet 41:43-9 (2011) DOI:10.1007/s10519-010-9395-4 PMID:17111266 著者 Shastry BS タイトル Developmental dyslexia: an update. 雑誌 J Hum Genet 52:104-9 (2007) DOI:10.1007/s10038-006-0088-z PMID:26283516 著者 Mannel C, Meyer L, Wilcke A, Boltze J, Kirsten H, Friederici AD タイトル Working-memory endophenotype and dyslexia-associated genetic variant predict dyslexia phenotype. 雑誌 Cortex 71:291-305 (2015) DOI:10.1016/j.cortex.2015.06.029 PMID:12954984 (DYX1) 著者 Taipale M, Kaminen N, Nopola-Hemmi J, Haltia T, Myllyluoma B, Lyytinen H, Muller K, Kaaranen M, Lindsberg PJ, Hannula-Jouppi K, Kere J タイトル A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain. 雑誌 Proc Natl Acad Sci U S A 100:11553-8 (2003) DOI:10.1073/pnas.1833911100 PMID:15717286 (DYX2) 著者 Cope N, Harold D, Hill G, Moskvina V, Stevenson J, Holmans P, Owen MJ, O'Donovan MC, Williams J タイトル Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia. 雑誌 Am J Hum Genet 76:581-91 (2005) DOI:10.1086/429131 |