| H01901 | |
| H番号 | H01901 |
| 名称 | バレット食道 |
| 概要 | Barrett esophagus (BE) is the premalignant lesion of esophageal adenocarcinoma (EAC) defined as specialized intestinal metaplasia (SIM) of the tubular esophagus. According to some studies, the incidence of the esophageal adenocarcinoma in patients with BE is of about 0.5% per year. The major pathogenetic factor in the development of BE is represented by the gastroesophageal reflux disease. BE is characterized by the replacement of the normal squamous epithelium with the columnar epithelium, when the healing of the lesion occurs. Because only a minority of patients (around 10-15%) with gastroesophageal reflux disease have BE, additional factors that play important roles in determining the development of BE must concur. Another frequent association with BE, is represented by nitrate, an increased age, Caucasian race, male sex and hiatal hernia. Recently, it has been reported that mutations in MSR1, ASCC1, and CTHRC1 are associated with this disease. |
| カテゴリ | 消化器系疾患 |
| ネットワーク | - |
| 病因遺伝子 | MSR1 [HSA:4481] [KO:K06558] CTHRC1 [HSA:115908] [KO:K25700] ASCC1 [HSA:51008] [KO:K18666] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | - |
| コメント | See also H01602 Gastroesophageal reflux disease (GERD) and H00017 Esophageal cancer. |
| リンク | ICD-11: DA23 ICD-10: K22.7 MeSH: D001471 OMIM: 614266 |
| 文献 | PMID:21461873 著者 Gilbert EW, Luna RA, Harrison VL, Hunter JG タイトル Barrett's esophagus: a review of the literature. 雑誌 J Gastrointest Surg 15:708-18 (2011) DOI:10.1007/s11605-011-1485-y PMID:25870690 著者 Gindea C, Birla R, Hoara P, Caragui A, Constantinoiu S タイトル Barrett esophagus: history, definition and etiopathogeny. 雑誌 J Med Life 7 Spec No. 3:23-30 (2014) PMID:21791690 著者 Orloff M, Peterson C, He X, Ganapathi S, Heald B, Yang YR, Bebek G, Romigh T, Song JH, Wu W, David S, Cheng Y, Meltzer SJ, Eng C タイトル Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma. 雑誌 JAMA 306:410-9 (2011) DOI:10.1001/jama.2011.1029 |