|Name||Helicobacter pylori infection|
|Description||Helicobacter pylori (HP) is a gram-negative pathogenic bacterium that specifically colonizes in the gastric epithelium and causes chronic gastritis, peptic ulcer disease, and/or gastric malignancies. Persistent infection can cause inflammation and gastritis that may lead to carcinogenesis. Transmission is still not entirely clarified, but human-to-human spread through oral-oral or fecal-oral route is thought to be the most plausible. The prevalence of HP infection varies between different geographical regions; generally, the prevalence is about 30% in developed and up to 80% in developing countries. Although HP may sometimes be eradicated by antibiotics given for other infections, infection usually persists life-long unless specific combination antibiotic therapy is taken.|
|Pathogen||Helicobacter pylori [GN:hpy hpj hpa hps hpg hpp hpb hpl hpi hpq hpw hef hpf heq hex hpv hey hpya hpyk hpyb hpyc hpyd hpye hpyf hpyg hpyh hpyj heb hez]
MODULE M00564 Helicobacter pylori pathogenicity signature, cagA pathogenicity island
|Drug||Omeprazole magnesium [DR:D05259]
Rabeprazole sodium [DR:D00724]
Esomeprazole magnesium [DR:D01984]
Esomeprazole magnesium dihydrate [DR:D11114]
Omeprazole, clarithromycin and amoxicillin [DR:D10246]
Amoxicillin hydrate, clarithromycin and lansoprazole [DR:D08774]
Bismuth subcitrate, tetracycline and metronidazole [DR:D10245]
Omeprazole magnesium, amoxicillin and rifabutin [DR:D11858]
|Other DBs||ICD-10: A49.8
|Reference||AUTHORS Papadakis MA, Tierney LM (ed).
TITLE [Current Medical Diagnosis & Treatment 2004, Forty-Third Edition] (In Japanese)
JOURNAL Nikkei Business Publications, Inc. (2004)
AUTHORS Albaker WI
TITLE Helicobacter pylori infection and its relationship to metabolic syndrome: is it a myth or fact?
JOURNAL Saudi J Gastroenterol 17:165-9 (2011)
AUTHORS Goh KL, Chan WK, Shiota S, Yamaoka Y
TITLE Epidemiology of Helicobacter pylori infection and public health implications.
JOURNAL Helicobacter 16 Suppl 1:1-9 (2011)
AUTHORS Kabir S
TITLE The current status of Helicobacter pylori vaccines: a review.
JOURNAL Helicobacter 12:89-102 (2007)
AUTHORS Moss SF, Sood S
TITLE Helicobacter pylori.
JOURNAL Curr Opin Infect Dis 16:445-51 (2003)