H00689 | |
H number | H00689 |
Name | Delayed sleep phase syndrome |
Description | Delayed sleep phase syndrome (DSPS) is characterized by a 3 to 6-hour delayed sleep schedule relative to the desired. The single nucleotide polymorphism (Ala129Thr) in Arylalkylamine N-acetyltransferase (AANAT), a rate-limiting enzyme in melatonin synthesis, has been identified in patients with delayed sleep phase disorder. |
Category | Nervous system disease |
Network | - |
Gene | AANAT (polymorphism) [HSA:15] [KO:K00669] CRY1 [HSA:1407] [KO:K02295] |
Pathogen | - |
Env factor | - |
Carcinogen | - |
Drug | - |
Comment | - |
Other DBs | ICD-11: 7A60 ICD-10: G47.2 MeSH: D020178 OMIM: 614163 |
Reference | PMID:21929966 AUTHORS Barion A TITLE Circadian rhythm sleep disorders. JOURNAL Dis Mon 57:423-37 (2011) DOI:10.1016/j.disamonth.2011.06.003 PMID:18845459 AUTHORS Bjorvatn B, Pallesen S TITLE A practical approach to circadian rhythm sleep disorders. JOURNAL Sleep Med Rev 13:47-60 (2009) DOI:10.1016/j.smrv.2008.04.009 PMID:12736803 AUTHORS Hohjoh H, Takasu M, Shishikura K, Takahashi Y, Honda Y, Tokunaga K TITLE Significant association of the arylalkylamine N-acetyltransferase ( AA-NAT) gene with delayed sleep phase syndrome. JOURNAL Neurogenetics 4:151-3 (2003) DOI:10.1007/s10048-002-0141-9 PMID:28388406 AUTHORS Patke A, Murphy PJ, Onat OE, Krieger AC, Ozcelik T, Campbell SS, Young MW TITLE Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder. JOURNAL Cell 169:203-215.e13 (2017) DOI:10.1016/j.cell.2017.03.027 |