H01360 | |
H number | H01360 |
Name | Allergic rhinitis |
Description | Allergic rhinitis (AR) is an inflammation of nasal mucosa mediated by IgE-associated processes, which is characterised by pruritus, sneezing, rhinorrhoea, and nasal congestion. The development of AR entails a complex interaction between genetic predisposition and environmental exposure to different factors, of which the most important is the implicated allergen. Single-nucleotide polymorphism studies involving genes encoding for molecules implicated in the pathogenesis of AR have also been made. Such molecules comprise chemokines and their receptors, interleukins and their receptors, eosinophil peroxidase and leukotrienes, among others. |
Category | Immune system disease |
Network | - |
Gene | GATA3 (polymorphism) [HSA:2625] [KO:K17895] IL-13 (polymorphism) [HSA:3596] [KO:K05435] IL-18 (polymorphism) [HSA:3606] [KO:K05482] IL-28RA (polymorphism) [HSA:163702] [KO:K05140] EPO (polymorphism) [HSA:2056] [KO:K05437] CCXCR1 (polymorphism) [HSA:2829] [KO:K04193] CCR1 (polymorphism) [HSA:1230] [KO:K04176] CCR2 (polymorphism) [HSA:729230] [KO:K04177] CCR3 (polymorphism) [HSA:1232] [KO:K04178] CCR5 (polymorphism) [HSA:1234] [KO:K04180] SDAD1 (polymorphism) [HSA:55153] [KO:K14856] CXCL9 (polymorphism) [HSA:4283] [KO:K05416] CXCL10 (polymorphism) [HSA:3627] [KO:K12671] CXCL11 (polymorphism) [HSA:6373] [KO:K12672] RANTES (polymorphism) [HSA:6352] [KO:K12499] Eotaxin-3 (polymorphism) [HSA:10344] [KO:K21096] CD14 (polymorphism) [HSA:929] [KO:K04391] FOXJ1 (polymorphism) [HSA:2302] [KO:K09402] FCGR2A (polymorphism) [HSA:2212] [KO:K06472] |
Pathogen | - |
Env factor | - |
Carcinogen | - |
Drug | Triamcinolone acetonide [DR:D00983] Dexamethasone [DR:D00292] Dexamethasone sodium phosphate [DR:D00975] Hydrocortisone [DR:D00088] Hydrocortisone sodium succinate [DR:D00978] Prednisolone [DR:D00472] Prednisolone sodium phosphate [DR:D00981] Prednisone [DR:D00473] Budesonide [DR:D00246] Beclomethasone dipropionate [DR:D00689] Beclomethasone dipropionate monohydrate [DR:D11572] Promethazine hydrochloride [DR:D00480] Clemastine fumarate [DR:D00666] Methylprednisolone [DR:D00407] Methylprednisolone sodium succinate [DR:D00751] Methylprednisolone acetate [DR:D00979] Mometasone furoate [DR:D00690] Fluticasone furoate [DR:D06315] Cortisone acetate [DR:D00973] Azithromycin [DR:D06390] Azelastine hydrochloride [DR:D00659] Olopatadine hydrochloride [DR:D01192] Ciclesonide [DR:D01703] Fexofenadine hydrochloride and pseudoephedrine hydrochloride [DR:D10252] Desloratadine and pseudoephedrine sulfate [DR:D10850] Montelukast sodium [DR:D00529] Carbinoxamine maleate [DR:D01336] Dexchlorpheniramine maleate [DR:D00668] Levocetirizine dihydrochloride [DR:D08118] Cyproheptadine hydrochloride [DR:D02234] Fexofenadine hydrochloride [DR:D00671] Desloratadine [DR:D03693] Azelastine hydrochloride and fluticasone propionate [DR:D11656] Olopatadine and mometasone furoate [DR:D12501] |
Comment | - |
Other DBs | ICD-11: CA08.0 ICD-10: J30 MeSH: C567078 OMIM: 607154 |
Reference | PMID:19476051 AUTHORS Davila I, Mullol J, Ferrer M, Bartra J, del Cuvillo A, Montoro J, Jauregui I, Sastre J, Valero A TITLE Genetic aspects of allergic rhinitis. JOURNAL J Investig Allergol Clin Immunol 19 Suppl 1:25-31 (2009) PMID:22053313 AUTHORS Pawankar R, Mori S, Ozu C, Kimura S TITLE Overview on the pathomechanisms of allergic rhinitis. JOURNAL Asia Pac Allergy 1:157-67 (2011) DOI:10.5415/apallergy.2011.1.3.157 PMID:21913195 AUTHORS Mucci T, Govindaraj S, Tversky J TITLE Allergic rhinitis. JOURNAL Mt Sinai J Med 78:634-44 (2011) DOI:10.1002/msj.20287 PMID:21783242 AUTHORS Greiner AN, Hellings PW, Rotiroti G, Scadding GK TITLE Allergic rhinitis. JOURNAL Lancet 378:2112-22 (2011) DOI:10.1016/S0140-6736(11)60130-X PMID:21784174 AUTHORS Mandhane SN, Shah JH, Thennati R TITLE Allergic rhinitis: an update on disease, present treatments and future prospects. JOURNAL Int Immunopharmacol 11:1646-62 (2011) DOI:10.1016/j.intimp.2011.07.005 PMID:18360551 AUTHORS Wang DY TITLE Risk factors of allergic rhinitis: genetic or environmental? JOURNAL Ther Clin Risk Manag 1:115-23 (2005) DOI:10.2147/tcrm.1.2.115.62907 PMID:24535140 AUTHORS Braido F, Arcadipane F, Marugo F, Hayashi M, Pawankar R TITLE Allergic rhinitis: current options and future perspectives. JOURNAL Curr Opin Allergy Clin Immunol 14:168-76 (2014) DOI:10.1097/ACI.0000000000000043 |