| H00322 | |
| H number | H00322 |
| Name | Epidemic typhus |
| Description | Epidemic typhus is caused by gram-negative rickettsia species in the typhus biogroup that are transmitted by infective louse and flea. The disease is widely distributed in tropical and subtropical areas. Most patients present with an acute febrile disease with constitutional symptom and maculopapular exanthema. |
| Category | Bacterial infectious disease |
| Network | - |
| Gene | - |
| Pathogen | Rickettsia prowazekii [GN:rpr rpq rpl rpn] (epidemic louse-borne typhus) Rickettsia typhi [GN:rty] (murine flea-borne typhus) |
| Env factor | - |
| Carcinogen | - |
| Drug | Tetracycline hydrochloride [DR:D02122] Doxycycline [DR:D00307] Doxycycline hyclate [DR:D02129] Doxycycline calcium [DR:D03903] Minocycline hydrochloride [DR:D00850] Demeclocycline hydrochloride [DR:D00290] |
| Comment | Vectors: Prediculus humanus (human body louse); Xenopsylla cheopis (rat flea) and Polyplax spinulos (rat louse) |
| Other DBs | ICD-11: 1C30 ICD-10: A75 MeSH: D014437 D014438 MedlinePlus: 001363 |
| Reference | PMID:15353963 AUTHORS Rolain JM, Jensenius M, Raoult D TITLE Rickettsial infections--a threat to travellers? JOURNAL Curr Opin Infect Dis 17:433-7 (2004) DOI:10.1097/00001432-200410000-00008 PMID:15546086 AUTHORS Jensenius M, Fournier PE, Raoult D TITLE Rickettsioses and the international traveler. JOURNAL Clin Infect Dis 39:1493-9 (2004) DOI:10.1086/425365 PMID:15845235 AUTHORS Parola P, Davoust B, Raoult D TITLE Tick- and flea-borne rickettsial emerging zoonoses. JOURNAL Vet Res 36:469-92 (2005) DOI:10.1051/vetres:2005004 |