| H00001 | |
| H番号 | H00001 |
| 名称 | B細胞急性リンパ性白血病; B細胞リンパ芽球性白血病 |
| 概要 | Acute lymphocytic leukemia (ALL) is a clonal stem cell malignancy of excessive lymphoblast proliferation. It is now understood that ALL and lymphoblastic lymphoma are the same disease entities at the morphologic and immunophenotypic levels and classified as either B- and T-cell lymphoblastic leukemia/lymphoma (B-ALL and T-ALL). In the case of B-ALL, numerous reports have demonstrated that recurring genetic abnormalities are associated with sufficiently unique clinical, immunophenotypic, and/or prognostic features so that they can be considered as distinct entities. The most common rearrangements observed in B-ALL are the t(12;21) (p13;q22) rearrangement resulting in expression of the ETV6-RUNX1 fusion (TEL-AML1); the t(1;19) (q23;p13) translocation that results in expression of the TCF3 (E2A) fusion partner, (also known as TCF3) TFPT-PBX1 fusion (E2A-PBX); the t(9;22) (q34;q11.2) "Philadelphia" chromosome resulting in expression of the BCR-ABL1 fusion; and rearrangements of MLL (also known as KMT2A) at 11q23 to a diverse array of fusion partners. If none of these specific genetic abnormalities are found, the designation of "B lymphoblastic leukemia/lymphoma, not otherwise specified," is appropriate. |
| カテゴリ | がん |
| ネットワーク | - |
| 病因遺伝子 | BCR-ABL (translocation) [HSA:25] [KO:K06619] MLL-AF4 (translocation) [HSA:4297 4299] [KO:K09186 K15184] E2A-PBX1 (translocation) [HSA:6929 5087] [KO:K09063 K09355] TEL-AML1 (translocation) [HSA:861] [KO:K08367] c-MYC (rearrangement) [HSA:4609] [KO:K04377] CRLF2 (rearrangement) [HSA:64109] [KO:K05078] PAX5 (rearrangement) [HSA:5079] [KO:K09383] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | ベタメタゾンリン酸エステルナトリウム [DR:D00972] トリアムシノロンアセトニド [DR:D00983] プレドニゾロン [DR:D00472] メチルプレドニゾロンコハク酸エステルナトリウム [DR:D00751] シクロホスファミド水和物 [DR:D00287] イホスファミド [DR:D00343] ブスルファン [DR:D00248] メルファラン [DR:D00369] ニムスチン塩酸塩 [DR:D01059] ラニムスチン [DR:D01760] メルカプトプリン水和物 [DR:D00161] シタラビン [DR:D00168] ゲムシタビン塩酸塩 [DR:D01155] エノシタビン [DR:D01633] フルダラビンリン酸エステル [DR:D01907] クロファラビン [DR:D03546] ブレオマイシン塩酸塩 [DR:D03229] ペプロマイシン硫酸塩 [DR:D02063] ドキソルビシン塩酸塩 [DR:D01275] ダウノルビシン塩酸塩 [DR:D01264] エピルビシン塩酸塩 [DR:D02214] アクラルビシン塩酸塩 [DR:D01911] ピラルビシン塩酸塩 [DR:D08386] イノツズマブオゾガマイシン [DR:D08933] (CD22陽性) ビンブラスチン硫酸塩 [DR:D01068] ビンクリスチン硫酸塩 [DR:D02197] ビンデシン硫酸塩 [DR:D01769] エトポシド [DR:D00125] ミトキサントロン塩酸塩 [DR:D02166] イマチニブメシル酸塩 [DR:D01441] (フィラデルフィア染色体陽性) ダサチニブ [DR:D03658] (フィラデルフィア染色体陽性) ダサチニブ水和物 [DR:D06414] (フィラデルフィア染色体陽性) ポナチニブ塩酸塩 [DR:D09951] (フィラデルフィア染色体陽性) ブリナツモマブ [DR:D09325] シスプラチン [DR:D00275] カルボプラチン [DR:D01363] L-アスパラギナーゼ [DR:D02997] ペグアスパルガーゼ [DR:D05387] ソブゾキサン [DR:D01404] クリサンタスパーゼ [DR:D10517] チサゲンレクルユーセル [DR:D11386] (CD19陽性) |
| コメント | - |
| リンク | ICD-11: 2A70 ICD-10: C83.5 C91.0 MeSH: D054198 |
| 文献 | PMID:25781572 著者 Roberts KG, Mullighan CG タイトル Genomics in acute lymphoblastic leukaemia: insights and treatment implications. 雑誌 Nat Rev Clin Oncol 12:344-57 (2015) DOI:10.1038/nrclinonc.2015.38 PMID:23023711 著者 Mullighan CG タイトル Molecular genetics of B-precursor acute lymphoblastic leukemia. 雑誌 J Clin Invest 122:3407-15 (2012) DOI:10.1172/JCI61203 PMID:18783329 著者 Teitell MA, Pandolfi PP タイトル Molecular genetics of acute lymphoblastic leukemia. 雑誌 Annu Rev Pathol 4:175-98 (2009) DOI:10.1146/annurev.pathol.4.110807.092227 PMID:19357394 著者 Vardiman JW, Thiele J, Arber DA, Brunning RD, Borowitz MJ, Porwit A, Harris NL, Le Beau MM, Hellstrom-Lindberg E, Tefferi A, Bloomfield CD タイトル The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. 雑誌 Blood 114:937-51 (2009) DOI:10.1182/blood-2009-03-209262 PMID:22449370 著者 Cornell RF, Palmer J タイトル Adult acute leukemia. 雑誌 Dis Mon 58:219-38 (2012) DOI:10.1016/j.disamonth.2012.01.011 PMID:27069254 著者 Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, Bloomfield CD, Cazzola M, Vardiman JW タイトル The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. 雑誌 Blood 127:2391-405 (2016) DOI:10.1182/blood-2016-03-643544 PMID:12556326 著者 Harrison JD, Muirhead CR. タイトル Quantitative comparisons of cancer induction in humans by internally deposited radionuclides and external radiation. 雑誌 Int J Radiat Biol 79:1-13 (2003) DOI:10.1080/0955300021000038671 |