| H00001 | |
| H number | H00001 |
| Name | B-cell acute lymphoblastic leukemia; B-cell acute lymphocytic leukemia |
| Description | Acute lymphocytic leukemia (ALL) is a clonal stem cell malignancy of excessive lymphoblast proliferation. It is now understood that ALL and lymphoblastic lymphoma are the same disease entities at the morphologic and immunophenotypic levels and classified as either B- and T-cell lymphoblastic leukemia/lymphoma (B-ALL and T-ALL). In the case of B-ALL, numerous reports have demonstrated that recurring genetic abnormalities are associated with sufficiently unique clinical, immunophenotypic, and/or prognostic features so that they can be considered as distinct entities. The most common rearrangements observed in B-ALL are the t(12;21) (p13;q22) rearrangement resulting in expression of the ETV6-RUNX1 fusion (TEL-AML1); the t(1;19) (q23;p13) translocation that results in expression of the TCF3 (E2A) fusion partner, (also known as TCF3) TFPT-PBX1 fusion (E2A-PBX); the t(9;22) (q34;q11.2) "Philadelphia" chromosome resulting in expression of the BCR-ABL1 fusion; and rearrangements of MLL (also known as KMT2A) at 11q23 to a diverse array of fusion partners. If none of these specific genetic abnormalities are found, the designation of "B lymphoblastic leukemia/lymphoma, not otherwise specified," is appropriate. |
| Category | Cancer |
| Network | - |
| Gene | BCR-ABL (translocation) [HSA:25] [KO:K06619] MLL-AF4 (translocation) [HSA:4297 4299] [KO:K09186 K15184] E2A-PBX1 (translocation) [HSA:6929 5087] [KO:K09063 K09355] TEL-AML1 (translocation) [HSA:861] [KO:K08367] c-MYC (rearrangement) [HSA:4609] [KO:K04377] CRLF2 (rearrangement) [HSA:64109] [KO:K05078] PAX5 (rearrangement) [HSA:5079] [KO:K09383] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | Cyclophosphamide [DR:D00287] Methotrexate [DR:D00142] Mercaptopurine [DR:D00161] Clofarabine [DR:D03546] Vincristine sulfate [DR:D02197] (Philadelphia chromosome-negative) Teniposide [DR:D02698] Doxorubicin hydrochloride [DR:D01275] Daunorubicin hydrochloride [DR:D01264] Mitoxantrone hydrochloride [DR:D02166] Imatinib mesylate [DR:D01441] (Philadelphia chromosome positive) Dasatinib [DR:D06414] (Philadelphia chromosome positive) Ponatinib hydrochloride [DR:D09951] (T315I positive, Philadelphia chromosome positive) Inotuzumab ozogamicin [DR:D08933] Blinatumomab [DR:D09325] (Philadelphia chromosome-negative) Tisagenlecleucel-T [DR:D11386] Asparaginase [DR:D02997] Pegaspargase [DR:D05387] Enocitabine [DR:D01633] Calaspargase pegol [DR:D10096] |
| Comment | - |
| Other DBs | ICD-11: 2A70 ICD-10: C83.5 C91.0 MeSH: D054198 |
| Reference | PMID:25781572 AUTHORS Roberts KG, Mullighan CG TITLE Genomics in acute lymphoblastic leukaemia: insights and treatment implications. JOURNAL Nat Rev Clin Oncol 12:344-57 (2015) DOI:10.1038/nrclinonc.2015.38 PMID:23023711 AUTHORS Mullighan CG TITLE Molecular genetics of B-precursor acute lymphoblastic leukemia. JOURNAL J Clin Invest 122:3407-15 (2012) DOI:10.1172/JCI61203 PMID:18783329 AUTHORS Teitell MA, Pandolfi PP TITLE Molecular genetics of acute lymphoblastic leukemia. JOURNAL Annu Rev Pathol 4:175-98 (2009) DOI:10.1146/annurev.pathol.4.110807.092227 PMID:19357394 AUTHORS Vardiman JW, Thiele J, Arber DA, Brunning RD, Borowitz MJ, Porwit A, Harris NL, Le Beau MM, Hellstrom-Lindberg E, Tefferi A, Bloomfield CD TITLE The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. JOURNAL Blood 114:937-51 (2009) DOI:10.1182/blood-2009-03-209262 PMID:22449370 AUTHORS Cornell RF, Palmer J TITLE Adult acute leukemia. JOURNAL Dis Mon 58:219-38 (2012) DOI:10.1016/j.disamonth.2012.01.011 PMID:27069254 AUTHORS Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, Bloomfield CD, Cazzola M, Vardiman JW TITLE The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. JOURNAL Blood 127:2391-405 (2016) DOI:10.1182/blood-2016-03-643544 PMID:12556326 AUTHORS Harrison JD, Muirhead CR. TITLE Quantitative comparisons of cancer induction in humans by internally deposited radionuclides and external radiation. JOURNAL Int J Radiat Biol 79:1-13 (2003) DOI:10.1080/0955300021000038671 |