| H00023 | |
| H番号 | H00023 |
| 名称 | 精巣癌 |
| 概要 | Testicular germ cell tumor (TGCT) comprises about 98% of all testicular neoplasms and is thereby the most common malignancy among young males. Overall, three different entities of TGCT can be distinguished: teratomas and yolk sac tumors of newborns and infants, seminomatous and nonseminomatous germ cell tumors of adolescents and young adults, and spermatocytic seminoma of elderly men. Recent studies of TGCTs have suggested that overexpression of cyclin D2 is a very early, possibly the oncogenic, event in GC tumorigenesis. |
| カテゴリ | がん |
| ネットワーク | - |
| 病因遺伝子 | CCND2 (amplification) [HSA:894] [KO:K10151] FGFR3 [HSA:2261] [KO:K05094] KIT [HSA:3815] [KO:K05091] STK11 [HSA:6794] [KO:K07298] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | シクロホスファミド水和物 [DR:D00287] イホスファミド [DR:D00343] ブレオマイシン塩酸塩 [DR:D03229] ビンブラスチン硫酸塩 [DR:D01068] エトポシド [DR:D00125] パクリタキセル [DR:D00491] シスプラチン [DR:D00275] カルボプラチン [DR:D01363] ネダプラチン [DR:D01416] |
| コメント | - |
| リンク | ICD-11: 2C80 ICD-10: C62 MeSH: D013736 OMIM: 273300 |
| 文献 | PMID:18042148 著者 Lind GE, Skotheim RI, Lothe RA タイトル The epigenome of testicular germ cell tumors. 雑誌 APMIS 115:1147-60 (2007) DOI:10.1111/j.1600-0463.2007.apm_660.xml.x PMID:10749107 著者 Chaganti RS, Houldsworth J. タイトル Genetics and biology of adult human male germ cell tumors. 雑誌 Cancer Res 60:1475-82 (2000) PMID:9791864 著者 Lutzker SG, Barnard NJ. タイトル Testicular germ cell tumors: molecular understanding and clinical implications. 雑誌 Mol Med Today 4:404-11 (1998) DOI:10.1016/S1357-4310(98)01329-X PMID:17683189 著者 Bahrami A, Ro JY, Ayala AG. タイトル An overview of testicular germ cell tumors. 雑誌 Arch Pathol Lab Med 131:1267-80 (2007) DOI:10.1043/1543-2165(2007)131[1267:AOOTGC]2.0.CO;2 PMID:9056671 (CCND2) 著者 Houldsworth J, Reuter V, Bosl GJ, Chaganti RS タイトル Aberrant expression of cyclin D2 is an early event in human male germ cell tumorigenesis. 雑誌 Cell Growth Differ 8:293-9 (1997) PMID:19855393 (FGFR3) 著者 Goriely A, Hansen RM, Taylor IB, Olesen IA, Jacobsen GK, McGowan SJ, Pfeifer SP, McVean GA, Rajpert-De Meyts E, Wilkie AO タイトル Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors. 雑誌 Nat Genet 41:1247-52 (2009) DOI:10.1038/ng.470 PMID:10362788 (KIT) 著者 Tian Q, Frierson HF Jr, Krystal GW, Moskaluk CA タイトル Activating c-kit gene mutations in human germ cell tumors. 雑誌 Am J Pathol 154:1643-7 (1999) DOI:10.1016/S0002-9440(10)65419-3 PMID:9605748 (STK11) 著者 Avizienyte E, Roth S, Loukola A, Hemminki A, Lothe RA, Stenwig AE, Fossa SD, Salovaara R, Aaltonen LA タイトル Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors. 雑誌 Cancer Res 58:2087-90 (1998) |